Summary
The interaction of diclofenac and ketoprofen, both applied intraperitoneally in a dose of 8 mg/kg for twenty-eight days, was assessed with cardioactive drugs in rats. Interaction was assessed on the basis of ECG records after the infusion of adrenaline, verapamil or lidocaine to the rats treated with diclofenac or ketoprofen vs control. The infusion time was measured in seconds to the moment of the appearance of the first heart reaction to the infusion of the cardioactive drug, then to the appearance of more frequent changes in the ECG record, and finally, to the occurrence of the toxic effect. It was also measured the plasma concentrations of sodium and potassium ions. As well as diclofenac and ketoprofen concentration, 2 hours after single and 28th dose. ECG patterns revealed no occurrence of cardiotoxic action of diclofenac and ketoprofen. The treatment with diclofenac caused significantly lower sodium plasma concentrations whereas the concentration of potassium was increased. Diclofenac concentrations were the same after a single and multiple doses, whereas concentrations of ketoprofen were significantly higher after a single dose than after its multiple applications.
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Turner R.A.: Screening Methods in Pharmacology, Academic Press, New York and London, 1965.
Owen S.G., Michael S.R., William T.F. (1987): Rapid High-performance liquid chromatographic assay for the simultaneus analysis of non-steroidal antiinflamatory drugs in plasma. J. Chromatogr., 416, 293–302.
USP. The United States Pharmacopeia. The national formulary. USP 26th revision (January 1, 2003). NF 2lst ed (January 1, 2003). Rockville, MD: The United States Pharmacopoeia Convention, Inc., 2002.
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Johnston S.A., Fox S.M. (1997): Mechanism of action of anti-inflammatory medications used for the treatment of osteoarthritis. J. Am. Veterin. Med. Assoc., 210, 1486–1492.
Oaks J.L., Gilbert M., Virani M.Z., Watson R.T., Meteyer C.U., Rideout B.A., Shivaprasad H.L., Ahmed S., Chaudhry M.J., Arshad M., Mahmood S., Ali A., Khan A.A (2004): Diclofenac residues as the cause of vulture population decline in Pakistan. Nature, 427, 630–633.
Noory T., Jarrar B.M.(2006): Histochemical Alterations in the Spleen of Rabbits Induced by Diclofenac Sodium (Voltaren). Science, 19, 21–29.
Masubuchi Y., Nakayama S., Hone T. (2002): Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology, 35, 544–551.
Hunter R.P., Isaza, R., Koch D.E. (2003): Oral bioavailability and pharmacokinetic characteristics of ketoprofen enantiomers after oral and intravenous administration in Asian elephants (Elephas maximus). Am. J. Veterin. Res., 64, 109–114.
Ishizaki T., Sasaki T., Suganuma T., Horai Y., Chiba K., Watanabe M., Asuke W., Hoshi H. (1980): Pharmacokinetics of ketoprofen following single oral, intramuscular and rectal doses and after repeated oral. Eur. J. Clin. Pharmacol., 18, 407–414.
Aberg G., Ciofalo V.B, Pendleton R.G., et al. (1995): Inversion of (R)- to (S)-ketoprofen in eight animal species. Chirality, 7, 383–387.
Lees P., Taylor P.M., Landoni F.M., Arifah A.K., Waters C. (2003): Ketoprofen in the Cat: Pharmacodyn. Chiral Pharmacokinet. Veterin. J. 165, 21–35.
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Jakovljevic, V., Sabo, A., Tomić, Z. et al. Interaction of diclofenac and ketoprofen with cardioactive drugs in rats. Eur. J. Drug Metabol. Pharmacokinet. 34, 11–17 (2009). https://doi.org/10.1007/BF03191378
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DOI: https://doi.org/10.1007/BF03191378