Summary
After oral and intravenous administration of drotaverin-14C its metabolites were determined in rat bile. Three major metabolites were identified by tlc. All the metabolites apeared in conjugated form. No unchanged drotaverine was detectable in the bile, except after treatment with doses much in excess of the therapeutic range. The ratio of major metabolites to unchanged product was determined by two-dimensional densitometry using a Telechrom Video Densitometer.
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References
Gábor G., Somogyi G. (1964): Die Wirkung von 6,7,3′,4′-tetraethoxy-1-benzal-1,2,3,4,-tetrahydro-isochinolin-hydrochlorid auf den coronarkreislauf. Arzneimittel Forschung, 14, 984–986.
Shimohira M., Nagasaka Y., Hojo H., Yoshifune S. (1969): Effects of No-Spa and papaverine on isolated atria and aorta in rabbit. (Report).
Petrányi G., Szegedi G. (1970): Comperative clinical study of the potency of spasmolytics. (Report).
Baumgartel P., Knapp E., Aigner A., Raas E. (1972): Kreislaufwirkungen von Drotaverine bei Gesunden mit ohne Isoproteronol-stimulation. Wiener Zeitschrift für Innere Medizin 10672.
Belpaire F.M., Bogaert M.G. (1973): Species Differences in the Excretion of Papaverine Metabolites. Arch. Int. Pharmacodyn., 208, 362.
Belpaire F.M., Bogaert M.G. (1973): The excretion of3-H-papaverine in the rat. Biochemical Pharmacology Vol. 22, 59–66.
Belpaire F.M., Bogaert M.G. (1975): Metabolism of Papaverine. Species Differences. Xenobiotica, Vol. 5, 431–438.
Gyarmati L., Dávid A. (1974): Data on the metabolism of Benzylisoquinoline Derivatives. Die Phamazie, 30, 1–4.
Magyar K., Lengyel M., Knoll J. (1978): Absorption, Distribution and Elimination of Drotaverine. Acta Physiologica Acad. Sci. Hung., 51/4/, 401–411.
Belpaire F.M., Bogaert M.G., Rosseel M.T. (1975): Metabolism of Papaverine. Xenobiotica, Vol. 5, 413–420.
Belpaire F.M., Bogaert M.G. (1975): Metabolism of Papaverine III. Xenobiotica, Vol. 5, 431–438.
Koltai E., Bánfi D., Wolford J., Mészáros Z. (1979): Synthesis of14C labelled Drotaverine. J. Labelled Compound, XVI. No. 2, 351–354.
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Vargay, Z., Simon, G., Winter, M. et al. Qualitative and quantitative determination of drotaverine metabolites in rat bile. European Journal of Drug Metabolism and Pharmacokinetics 5, 69–74 (1980). https://doi.org/10.1007/BF03189448
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DOI: https://doi.org/10.1007/BF03189448