Abstract
In order to evaluate the lung and brain uptake of99mTc ethyl cysteinate dimer(99mTc-ECD) and N-isopropyl-p-[123I]-iodoamphetamine (123I-IMP), alternative body scans were carried out in 15 cases of cerebrovascular disease. The biodistribution of99mTc-ECD was 5.5±O.7%, 3.8±0.7% in the brain; 13.1±3.7%, 2.2±1.2%, in the lung at 15 min and at 4 hours, respectively, whereas that of123I-IMP was 3.9±1.4%, 5.0±1.0% in the brain; 32.2±7.6%, 12.7±3.3%, in the lung at 15 rain and at 4 hours, respectively.99mTc-ECD accumulated in comparatively high amounts in the brain but remained low in the lung in the early image compared to123I-IMP. However there was a high inverse correlation between brain and lung uptake of123I-IMP (r=-0.82), but not of99mTc-ECD (r=-0.18).
We concluded that99mTc-ECD had a better biodistribution in terms of low lung accumulation than123I-IMP in brain SPECT.
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References
Vallabhajosula S, Zimmerman RE, Picard M, et al: Technetium-99m ECD: A new brain imaging agent:In vivo kinetics and biodistribution studies in normal human subjects.J Nucl Med 30: 599–604, 1989
Walovovitch RC, William SI, Morgan RA, et al: Pharmacological characterization of99mTc-ECD in non-human primates as a new agent for brain perfusion imaging [Abstract].J Nucl Med 29: 788, 1988
Walovovitch RC, Hall KM, O’Toole JJ, et al: Metabolism of99mTc-ECD in normal volunteer [Abstract].J Nucl Med 29: 747, 1988
Winchell HS, Baldwin RM, Lin TH: Development of123I-labelled amines for brain studies: Localization of123I iodophenylalkyl amines in rat brain.J Nucl Med 21: 940–946, 1980
Winchell HS, Horst WD, Braun L, et al: N-isopropyl-[123I]-p-iodoamphetamine: Single-pass brain uptake and washout; Binding to brain synaptosomes; and localization in dogs and monkey brain.J Nucl Med 21:947–952, 1980
Holman BL, Zimmerman RE, Schapiro JR, et al: Biodistribution and dosimetry of N-isopropyl-p-[123I]iodoamphetamine in the primate.J Nucl Med 24:922–931, 1982
Kuhl DE, Barrio JR, Huang S, et al: Quantifying local cerebral blood flow by N-isopropyl-p-[123I] iodoamphetamine (IMP) tomography.J Nucl Med 23: 196–203, 1982
Touya JJ, Rahimian J, Corbus HF, et al: The lung as a metabolic organ.Semin Nucl Med 16: 296–305, 1986
Hayashida K, Nishimura T, Uehara T, et al: Clinical application of99mTc HMPAO as cerebral perfusion imaging.Jpn J Nucl Med 25: 231–240, 1988
Holman BL, Zimmerman RE, Scapiro JR, et al: Biodistribution and donsimetry of N-isopropyl-p-[123I]Iodoamphetamine in the primate.J Nucl Med 24: 922–931, 1983
Holman BL, Hellman RS, Goldsmith SJ, et al: Biodistribution, Dosimetry, and Clinical evaluation of99mTc ethly cysteinate dimer in normal subjects and in patients with chronic cerebral infarction.J Nucl Med 30: 1018–1024, 1989
Katoh K, Takahashi T: Effect of cigarette smoking on123I-IMP clearance from the lung.Jpn J Nucl Med 27: 1093–1098, 1990
Mueller SP, Polak JF, Kijewski MF, et al: Collimator selection for SPECT brain imaging: The advantage of high resolution.J Nucl Med 2 : 1729–1738, 1986
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Hayashida, K., Nishimura, T., Imakita, S. et al. Favorable biodistribution of99mTc-ECD for brain SPECT comparing with123I-IMP using alternative body scan. Ann Nucl Med 6, 229–233 (1992). https://doi.org/10.1007/BF03164659
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DOI: https://doi.org/10.1007/BF03164659