Abstract
Technetium-99m-HMPAO (Tc-99m-HMPAO) labeled leukocyte imaging was carried out in 19 patients at 3–5 hr after reinjection. There were no side effects noted. Tc-99m leukocyte images showed gall bladder, colon, kidney, and urinary bladder activity in normal distribution as a result of excretion of the eluted Tc-99m complex. They yielded a sensitivity of 93%, a specificity of 100% and an accuracy of 95%. They were correctly positive in 14 out of 19 cases. But one false negative case was seen in a patient with pyonephrosis showing a lack of renal function with decreased renal blood flow. It was concluded that they have some advantages over In-111 leukocyte images, but we have to consider the fact that the ureteral obstruction or the lack of renal function with decreased renal blood flow may result in a false positive or a false negative case.
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References
Thakur ML, Lavender JP, Arnot RN, et al: Indium-111 labeled autologous leukocytes in man.J Nucl Med 18: 1014–1021, 1977
Uno K: Basic and clinical study of In-111-oxine labeled leukocytes for detection of inflammatory foci.Nippon Act Radiol 42: 565–575, 1982
Uno K, Yamaura A, Uchiyama G, et al: Evaluation of In-111-leukocyte imaging in patients with intra-cranial lesions. InRadiolabeled Cellular Blood Elements Thakur M, (ed.), New York, Plenum Press, pp 417–418, 1985
Uno K, Matsui N, Nohira K, et al: Indium-111 leukocyte imaging in patient with rheumatoid arthritis.J Nucl Med 27: 339–344, 1986
Uno K, Imazeki K, Arimizu N, et al: The complementary role of Indium-111 labeled leukocyte imaging, ultrasonography and computed tomography in the evaluation of postoperative infection or abscess.Ann Nucl Med 1: 27–31, 1987
Uno K, Imazeki K, Arimizu N, et al: Indium-111 labeled leukocytes for an inflammatory scintigraphy.Jpn J Clin Radiol 33: 249–255, 1988
Terauchi T, Uno K, Yuyama T, et al: Clinical usage of Indium-111 labeled leukocyte scintigraphy and Technetium-99m Methylene Diphosphonate scintigraphy in patients with total hip replacement.Kaku Igaku 25: 1103–1109, 1988
Segal AW, Deteix P, Gareia R, et al: Indium-111 labeling of leukocytes: A deterimental effect on neutrophil and lymphocyte function and an improved method of cell labeling.J Nucl Med 19: 1238–1244, 1978
Ell PJ, Hocknell JML, Jarritt PH, et al: A technetium-99m labelled radiotracer for the investigation of cerebral vascular disease.Nucl Med Common 6: 437–441, 1985
Peters AM, Danpure HJ, Osman S, et al: Preliminary clinical experience with Tc-99m-HM-PAO for labelling leukocytes and imaging infection.Lancet 2: 946–949, 1986
Danpure HJ, Osman S, Carroll MJ, et al:In vitro studies to develop a clinical protocol for radio-labeling mixed leukocytes with Tc-99m HMPAO.J Nucl Med 28: 694, 1987
Roddie ME, Peters AM, Henderson BL, et al: Imaging inflammation with Tc-99m HMPAO labelled with cells.J Nucl Med 28: 648, 1987
Uno K, Imazeki K, Yoshikawa K, et al: Clinical use of technetium-99m HMPAO labeled leukocytes for inflammatory imaging.J Nucl Med 28: 648, 1987
Rao SA, Aksut G, Trembath LA, et al: Evaluation of Tc-99m HMPAO for leukocyte labeling.J Nucl Med 28: 638, 1987
Roddie ME, Peters AM, Danpure HJ, et al: Imaging inflammation with Tc-99m hexamethyl propylene amine oxime (HM-PAO).Radiol 166: 767–772, 1988
McAfee JG, Subramanian G, Gagne G, et al: Tc-99m-HM-PAO for labeling experimental comparison with In-111-oxine in dogs.Eur J Nucl Med 13: 353–357, 1987
Danpure HJ, Osman S, Carroll MJ. The development of a clinical protocol for the radiolabelling of mixed leukocytes with Tc-99m hexamethylpropyleneamine oxime.Nucl Med Commun 9: 465–475, 1988
Solanki KK, Mather SJ, Janabi MAL, et al: A rapid method for the preparation of Tc-99m hexametazime labelled leukocytes.Nucl Med Commun 9: 753–761, 1988
Vorne M, Soini I, Lantto T, et al: Technetium-99m HM-PAO-labeled leukocytes in detection of inflammatory lesions: Comparison with Gallium-67 citrate.J Nucl Med 30: 1332–1336, 1989
Mountford PJ, Kettle AG, O’Doherty MJ, et al: Comparison of Tc-99m-HM-PAO leukocytes with Indium-111-oxine leukocytes for localizing intra-abdominal sepsis.J Nucl Med 31: 311–315, 1990
Mock BH, Schauwecker DS, English D, et al:In vivo kinetics of canine leukocytes labeled with technetium-99m HM-PAO and Indium-Ill tropolonate. J NuclMed 29: 1246–1451, 1988
Mortelmans L, Malbrain S, Stuyck J, et al:In vitro andin vivo evaluation of granulocyte labeling with Tc-99m d,l-HM-PAO.J Nucl Med 30: 2022–2028, 1989
Ecclestone M, Proulx A, Ballinger JR, et al:In vitro comparison of HMPAO and gentisic acid for labelling leukocytes with Tc-99m.Eur J Nucl Med 16: 299–302, 1990
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Uno, K., Yoshikawa, K., Imazeki, K. et al. Technetium-99m HMPAO labeled leukocytes in inflammation imaging. Ann Nucl Med 5, 77–81 (1991). https://doi.org/10.1007/BF03164618
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DOI: https://doi.org/10.1007/BF03164618