Abstract
The influence of spinal tetracaine on central nervous system (CNS) metabolism was determined during nociceptive stimulation. Rats were divided into a halothane group in which the sciatic nerve was stimulated during 0.5 per cent halothane anaesthesia, a tetracaine group in which the sciatic nerve was stimulated during a simultaneous tetracaine spinal and 0.5 per cent halothane anaesthetic, or an awake group. Autoradiographic determination of local spinal cord and cerebral glucose utilization was performed usingl4C-2-deoxyglucose. Central nervous system metabolism was greater in the halothane group than the tetracaine and awake groups (P < 0.05). The only meaningful differences between the tetracaine and awake groups were in two lumbar grey areas at the site of drug administration where metabolism was decreased in the tetracaine/stimulated group. These results indicate that spinal tetracaine effects a decrease in metabolism locally, and attenuates increases in metabolism throughout the CNS observed during somatosensory stimulation.
Résumé
Nous avons mesuré par autoradiographie aul4C-2-déoxyglucose, l’effet d’une injection spinale de tétracaïne sur le métabolisme du cerveau et de la moelle épinière lors d’une stimulation douloureuse. On stimulait le nerf sciatique des rats du groupe halothane, anesthésiés avec de l’halothane à 0,5 pour cent et on faisait de même avec ceux du groupe tétracaïne auquel l’anesthésie a l’halothane 0,5 pour cent était associée à un bloc spinal à la tétracaïne. On disposait aussi d’un groupe éveillé (contrôle). L’activité métabolique cérébrate s’est avérée plus grande dans le groupe halothane que dans les deux autres (P < 0,05). En fait, seul un métabolisme diminué dans les deux zones grises lombaires (au site de l’injection), distinguait le groupe tétracaïne du groupe éveillé. II semble done que la tétracaïne puisse réduire localement le métabolisme de la moelle épinière et entraver l’augmentation du métabolisme cérébral associée à une stimulation somatosensorielle.
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Cole, D.J., Lin, D.M., Drummond, J.C. et al. Spinal tetracaine decreases central nervous system metabolism during somatosensory stimulation in the rat. Can J Anaesth 37, 231–237 (1990). https://doi.org/10.1007/BF03005475
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DOI: https://doi.org/10.1007/BF03005475