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A modern conception of gastric secretory functions

Based upon recent investigations and newer interpretations

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The American Journal of Digestive Diseases

Conclusion

The influence of pepsin on antipernicious anemia activity of gastric tissue cannot be disregarded. An understanding of its exact rôle will require further study.

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References

  1. Glaessner, K. and Wittgenstein, H.: Ein Neuer Weg Zur Funkstionsprüfung des Gesunden und Kranken Magens.Klin. Wchnschr., 2:1650, Aug. 27, 1923. Gastric Function Test.Archiv. fürVerdauungskr., 34:303, Feb., 1925. Glaessner, K.: Chromoskopie des Magens.Med. Klin., 22:887-889, June 4, 1926.

    Article  CAS  Google Scholar 

  2. Klein, E.: Gastric Secretion After Partial Gastrectomy.J. A. M. A., 89:1235, 1927. Gastric Secretion: V. Achlorhydria Following Partial Gastrectomy for Ulcer; Studies with Histamine and the Transplanted Gastric Pouch.Arch. Surg., 30:162, Jan., 1935.

    Google Scholar 

  3. Henning, N. and Jürgens, R.: Beziehungen der Farbstoffexkretion zur Sekretion und Morphologie des Kranken Magons.Munchen. med. Wchnschr., 77:1961, Nov. 14, 1930.

    Google Scholar 

  4. Henning, N. and Bach, E.: Determination of the Function of the Glands of the Fundus and of the Pylorus by the Clinical Method of Combined Gastric Function Test.Arch. f. Verdauungskrankh, 49:155, 1931.

    Google Scholar 

  5. Morrison, S., Reeves, D. L. and Gardner, R. E.: The Elimination of Various Dyes from the Pavlov Pouch of Dogs.Am. Jour. Dig. Die. and Nutrit., 3:551–557, Oct., 1936.

    CAS  Google Scholar 

  6. Morrison, S., Gardner, R. E. and Reeves, D. L.: The Selective Elimination of Neutral Red Through the Gastric Mucosa.Jour. Lab. and Clin. Med., 21:822–828, May, 1936.

    CAS  Google Scholar 

  7. Kobayashi, K.: Experimental Studies on Absorption, Secretion and Excretion. On the Secretion and Absorption of Dyestuffs by the Stomach. I. On the Secretion of Dyestuffs into the Stomach.Acta Scholae Med., VIII, 465:468, 1926. II. Functional Test on the Stomach with Dyestuffs.Acta Scholae Med., VIII, 489, 1926.

    Google Scholar 

  8. Henning, N.: The Excretion of Dyestuffs Through the Gastric Mucosa. Microscopical Investigations on Living Animals.Arch, f. exper. Path. u. Pharmek., 165:191–207, Jan., 1932.

    Article  CAS  Google Scholar 

  9. Morrison, S.: The Importance of the Oxyntic Cell in Pernicious Anemia.Jour. Lab. and Clin. Med., 21:828–829, May, 1936.

    Google Scholar 

  10. Davidson, L. S. P.: Pernicious Anemia with Return of Hydrochloric Acid and Ferments After Treatment.Brit. Med. Jour., 1:182, Feb. 4, 1933.

    Google Scholar 

  11. Dodds, E. C., Noble, R. L. and Smith, E. R.: A Gastric Lesion Produced by an Extract of the Pituitary Gland.Lancet, 2:918, Oct. 27, 1934.

    Article  Google Scholar 

  12. Dodds, E. C. and Noble, R. L.: Relation of the Pituitary Lobe of the Pituitary Gland to Anaemia and to Blood Formation.Nature, 135:788, May 11, 1935.

    Article  Google Scholar 

  13. Dodds, E. C., Hills, G. M., Noble, R. L. and Williams, P. C.: The Posterior Lobe of the Pituitary Gland, Its Relationship to the Stomach and to the Blood Picture.Lancet, 1:1099, May 11, 1935.

    Article  Google Scholar 

  14. Cutting, W. C., Dodds, E. C., Noble, R. L. and Williams, P. C.: Pituitary Control of Alimentary Blood Flow and Secretion. The Effect of Alterations in Blood Flow on Gastric Secretion.Proc. Roy. Soc. of London, 123:39, June, 1937.

    CAS  Google Scholar 

  15. Cutting, W. C., Dodds, E. C., Noble, R. L. and Williams, P. C.: Pituitary Control of Alimentary Blood Flow and Secretion. Gastric Secretion and Blood Flow in Hypoplysectromized Animals.Proc. Roy. Soc. of London, 123:49, June, 1937.

    Article  CAS  Google Scholar 

  16. Morrison, S.: A Concept Offered in Explanation of Certain Cases of Pernicious Anemia.International Clinics, 1:89, March, 1986.

    Google Scholar 

  17. Braun, B.: Mechanism of Therapeutic Action of Castle's Principle in Pernicious Anemia.Folia Haemat, 53:27, 1934.

    CAS  Google Scholar 

  18. Meulengracht, E. and Schiodt, E.: Pepsin and Rennin Activity in Preparations of Dried Stomach Substance from Cardiac, Fundic and Pyloric Portion, Respectively (Preliminary Report).Ugesk. f. laeger., 96:187, 1934.

    Google Scholar 

  19. Greenspon, E. A.:The Nature of the Antipernicious Anemia Principle in Stomach.J. A. M. A., 106:266, Jan. 25, 1936.

    CAS  Google Scholar 

  20. Morrison, S. and Gardner, R. E.: A Pyloric Hormone in Pernicious Anemia.Med. Rev. of Rev., 42:339–871, Aug., 1936.

    Google Scholar 

  21. Meulengracht, E.: The Glands of the Stomach in Relation to Pernicious Anemia; with Special Reference to the Glands in the Pyloric Region.Proc. Roy. Soc. of Med. (Section on Medicine), 28:841, 1935.

    CAS  Google Scholar 

  22. Lim, R. K. S.: The Question of a Pyloric Hormone.Quarterly Jour. Exp. Phys., 13:79, 1922-23.

    Google Scholar 

  23. Ivy, A. C.: Gastro-Intestinal Principles.J. A. M. A., 105:506, 1935.

    Google Scholar 

  24. Castle, W. B.: The Etiology of Pernicious and Related Macrocytic Anemias. The Harvey Lectures, 30:37, 1934-35.

    Google Scholar 

  25. Goldhamer, S. M.: Relationship Between Gastric Juice Volume and Erythropoiesis in Patients with Untreated Pernicious Anemia.Proc. Soc. Exp. Biol. and Med., 32:476, 1934.

    Google Scholar 

  26. Castle, W. B. and Minot, G. R.: Pathological Physiology and Clinical Description of the Anemias.Oxford Med. Publications, 1936.

  27. Castle, W. B., Heath, C. W. and Strauss, M. B.: Observations on the Etiologic Relationship of Achylia Gastrica to Pernicious Anemia.Am. Jour. Med. Sci., 182:741, 1931.

    Google Scholar 

  28. Barnett, C. W.: The Significance of the Gastric Secretions in Pernicious Anemia.Am. Jour. Med. Sci., 182:170, 1931.

    Article  Google Scholar 

  29. Strauss, M. B. and Castle, W. B.: Studies of Anemia in Pregnancy; Etiologic Relationship of Gastric Secretory Defects and Dietary Deficiency to Hypochromic and Macrocytic (Pernicious) Anemias of Pregnancy and Treatment of These Conditions.Am. Jour. Med. Sci., 185:589, 1933.

    Article  Google Scholar 

  30. Schiff, L. and Tahl, T.: Effects of Dessicated Hog’s Stomach in Achlorhydria.Am. Jour. Dig. Dis. and Nutrit., 1:543, Oct., 1934.

    CAS  Google Scholar 

  31. Morris, R. S., Schiff, L., Foulger, J. H., Rich, M. L. and Sherman, J. E.: Observations on the Hematopoietic Hormone (Addlsin) in Pernicious Anemia.Brit. Med. Jour., 2:1050, 1932.

    Google Scholar 

  32. Fouts, P. J., Helmer, O. M. and Zerfas, L. G.: Hematopoietic Response to Intramuscular Injections ofConcentrated Human Gastric Juice. Brit. Med. Jour., 1:141, Jan., 1934.

    Google Scholar 

  33. Morrison, S.: Newer Interpretations and Conceptions of Gastric Mucosal Functions. I. Further Advances in the Study of Gastric Achylia. II. Evidence Suggesting a Role for the Oxyntic Cell in Pernicious Anemia. (To be published).

  34. Murray, M. M.: The Small Intestine and Gastric Secretion. With Special Reference to Brunner’s Glands.Jour, of Physiol., 69:48, 1930.

    CAS  Google Scholar 

  35. Aschner, O. W. and Grossman, S.: Gastritis and Duodenitis in Relation to the Ulcer Problem. S.G. O., 57:334, 1933.

    Google Scholar 

  36. Downs, A. W. and Eddy, N. B.: The Influence of Secretin on the Number of Erythrocytes in the Circulating Blood.Am. Jour. Physiol., 43:415, 1917. III. Secretin. Its Mode of Action in Producing an Increase in the Number of Corpuscles in the Circulating Blood.Am. Jour. Physiol., 46:209, 1918. V. Secretin. Its Effect in Anemia, with a Note on the Supposed Similarity Between Secretin and Vitamin B.Am. Jour. Physiol., 58:296, 1921. 36. Morrison, S.: Studies in Pernicious Anemia. An Inquiry into the Role of Pepsin. (To be published)Annals of Int. Med.

    Google Scholar 

  37. Henning, N. and Brugsch, H.: Ueber die Verteilung des änti- anamischen Faktors in der Magenschleimhaut.Deutsche med. Wchnschr., 57:757, May, 1931.

    Article  Google Scholar 

  38. Gutzeit, K. and Herrman, J.: The Effect of Stomach Substance on Pernicious Anemia. (Natural Gastric Juice, Pyloric and Fundic Mucosa, Wall of the Small Intestine).München med. Wchnschr., 78:266, Feb., 1931.

    Google Scholar 

  39. Henning, N. and Stieger, G.: Die Bchandlung der Perniziösen Anämie mit Magenschleimhaut Praparaten.Klin. Wchnschr., 9:2145, Nov., 1930.

    Article  CAS  Google Scholar 

  40. Henning, N.: Ueber den Ursprung des Antiperniziosa-Prinzips.Med. Welt., 8:1145, Aug., 1934.

    Google Scholar 

  41. Morrison, S.: A Comparison of the Antipernicious Anemia Potency of Depepsinized and Undepepsinized Gastric Mucosa. (To be published)Jour. Lab. and Clin. Med.

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Authors and Affiliations

  1. School of Medicine, University of Maryland, Maryland

    Samuel Morrison & Baltimore Maryland

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  1. Samuel Morrison
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  2. Baltimore Maryland
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Morrison, S., Maryland, B. A modern conception of gastric secretory functions. American Journal of Digestive Diseases 5, 617–627 (1938). https://doi.org/10.1007/BF02996484

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