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Neutralizing effect of zinc oxide on dehydroabietic acid-induced toxicity on human polymorphonuclear leukocytes

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Abstract

The cytotoxic effect of dehydroabietic acid (DHAA), a resin acid found in rosin, was studied on human polymorphonuclear leukocytes using leakage of51Cr from prelabeled cells, supravital staining, and transmission electron microscopy. DHAA caused a strong dose-related release of51Cr, a high uptake of trypan blue, and total cell necrosis, as seen in transmission electron microscopy. Albumin slightly reduced the toxic effects, whereas the addition of zinc in various forms strongly inhibited these toxic effects of DHAA in the concentration range of 10–500 μg/mL. In the presence of albumin, zinc oxide as a suspension inhibited the damage of the cell membranes more than a filtrate of zinc oxide, indicating a subsequent slow release of zinc from the zinc oxide.

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Authors and Affiliations

  1. Department of Oral Surgery, University of Umeå, Umeå, Sweden

    B. Sunzel

  2. Department of Hand Surgery, University of Umeå, Umeå, Sweden

    T. A. Söderberg

  3. Department of Pathology and Nutritional Research, University of Umeå, Umeå, Sweden

    C. -O. Reuterving & G. Hallmans

  4. Department of Clinical Bacteriology, University of Umeå, Umeå, Sweden

    S. E. Holm

  5. Department of Periodontology, University of Umeå, Umeå, Sweden

    L. Hänström

Authors
  1. B. Sunzel
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  2. T. A. Söderberg
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  3. C. -O. Reuterving
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  4. G. Hallmans
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  5. S. E. Holm
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  6. L. Hänström
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Sunzel, B., Söderberg, T.A., Reuterving, C.O. et al. Neutralizing effect of zinc oxide on dehydroabietic acid-induced toxicity on human polymorphonuclear leukocytes. Biol Trace Elem Res 30, 257–266 (1991). https://doi.org/10.1007/BF02991420

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  • DOI: https://doi.org/10.1007/BF02991420

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