Abstract
The aim of this study was to evaluate the usefulness of deep inspiration breath-hold SPECT (BrST, a method for201T1 SPECT) in the diagnosis of solitary pulmonary nodules (SPN).Methods: Ten patients with malignant lesions and five with benign lesions were enrolled in this study. Early SPECT acquisition was performed 15 min after injection of201T1, while delayed SPECT images were acquired 3 h after injection. The first 15-sec acquisition was done using the BrST technique, and the second with the conventional free breathing (FB) method. We performed this technique alternately, and therefore, the odd data were from BrST and the even data were from FB. We referred to the T/N ratio of the early images as the ER and to the T/N ratio of the delayed images as the DR. To semi-quantitatively evaluate the degree of retention in the lesion, the retention index (RI) was calculated.Results: The RI of BrST indicated greater accuracy than that of FB in the differential diagnosis of SPN. For the benign and malignant lesions, the RI of BrST was -3.07 ± 31.51 and 29.86 ± 25.01, respectively (p < 0.05). The sensitivity, specificity, and accuracy of BrST (80%, 80%, and 80%, respectively) were significantly higher than those of FB (p < 0.05).Conclusion: The BrST method is more accurate than that of the conventional FB method in the differential diagnosis of SPN.
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References
Chin BB, Zukerberg BW, Buchpiguel C, Alavi A. Thallium-201 uptake in lung cancer.J Nucl Med 1995; 36: 1514–1519.
Tonami N, Yokoyama K, Shuke N, Taki N, Kinuya S, Michigishi T, et al. Evaluation of suspected malignant pulmonary lesions with Tl-201 single-photon emission computed tomography.Nucl Med Commun 1993; 14:602–610.
Suga K, Kume N, Orihashi N, Nishigauchi K, Uchisato H, Matsumoto T, et al. Difference in Tl-201 accumulation on single photon emission computed tomography in benign and malignant lesions.Nucl Med Commun 1993; 14:1071–1078.
Ikeda E, Taki J, Kinuya S, Nakajima K, Tonami N. Thallium-201 SPECT with triple-headed gamma camera for differential diagnosis of small pulmonary nodular lesion 20 mm in diameter or smaller.Ann Nucl Med 2000; 14: 91–95.
Tonami N, Shuke N, Yokoyama K, Tsuchiya S, Kawai K, Nakagawa S, et al. Thallium-201 single photon emission computed tomography in the evaluation of suspected lung cancer.J Nucl Med 1989; 30: 997–1004.
Flores LG, Ochiai E, Nagamachi S, Jinnouchi S, Ohnishi T, Futami S, et al. The diagnostic role of201Tl SPECT imaging in patients with lung tumors: Comparison with computed tomography.Nucl Med Commun 1996; 17: 493–499.
Lewis P, Griffin S, Marsden P, Gee T, Numan T, Malsey M, et al. Whole-bodyl8F-fluorodeoxyglucose positron emission computed tomography in preoperative evaluation of lung cancer.Lancet 1994; 344: 1265–1266.
Higashi K, Nishikawa T, Seki H, Oguchi M, Nambu Y, Ueda Y, et al. Comparison of fluorine-18-FDG PET and Tl SPECT in evaluation of lung cancer.J Nucl Med 1998; 39: 9–15.
Higashi K, Ueda Y, Sakuma T, Seki H, Oguchi M, Taki S, et al. Comparison of F-18 FDG PET and Tl-201 SPECT in evaluation of pulmonary nodules.J Nucl Med 2001; 42: 1489–1496.
Horiuchi S, Hayashi M, Sugibayashi K. Development of Deep Breath-Hold SPECT [abstract].J Nucl Med 2004: P1560.
Osman MM, Cohade C, Nakamoto Y, Marshall LT, Leal JP, Wahl RL. Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients.J Nucl Med 2003; 44: 240–243.
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Komori, T., Narabayashi, I., Hayashi, M. et al. Evaluation of breath-hold201Tl SPECT in the differential diagnosis of solitary pulmonary nodules. Ann Nucl Med 19, 277–281 (2005). https://doi.org/10.1007/BF02984619
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DOI: https://doi.org/10.1007/BF02984619