Abstract
This study concerns a patient with minor (m)-BCR/ABL transcript-positive and Philadelphia (Ph) chromosome-negative myelodysplastic syndrome (MDS). The patient was a 78-year-old man whose condition was diagnosed as refractory anemia with excess of blasts in transformation. Molecular genetic studies, using reverse transcriptase polymerase chain reaction analysis detected m-BCR/ABL messenger RNA. We used spectral karyotyping to analyze metaphase cells but could not detect a Ph chromosome. Fluorescence in situ hybridization, however, revealed fusion signals ofBCR andABL probes on an apparently normal chromosome 22.
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Wakayama, T., Maniwa, Y., Ago, H. et al. A Variant Form of Myelodysplastic Syndrome With Ph− Minor-BCR/ABL Transcript. Int J Hematol 74, 58–63 (2001). https://doi.org/10.1007/BF02982550
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DOI: https://doi.org/10.1007/BF02982550