Summary
The probability that a new mutant will have its locus iu the neighbourhood of a known marker gene depends onL, the total genetical map length of the organism; it should therefore be possible to use the observed frequency of such events to obtain an estimate ofL. A procedure is described whereby this can be done. Applied to the house mouse, it givesL = 16.2 ± 3.5 M.; this agrees well with recent estimates based on cytological data. The method may be valuable as an alternative or adjunct to the method of chiasma counts.
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Caster, T.C. The estimation of total genetical map lengths from linkage test data. Journ. of Genetics 53, 21–28 (1955). https://doi.org/10.1007/BF02981505
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DOI: https://doi.org/10.1007/BF02981505