Abstract
Introduction: We report a case of rapidly growing fibroadenoma.
Patient: A 13-year-old girl consulted the outpatient clinic regarding a left breast mass. The mass was diagnosed as fibroadenoma by clinical examinations, and the patient was carefully monitored. The mass enlarged rapidly with each menses and showed a 50% increase in volume four months later. Lumpectomy was performed. The tumor was histologically diagnosed as fibroadenoma organized type and many glandular epithelial cells had positive immunohistochemical staining for anti-estrogen receptor antibody in the nuclei.
Conclusion: The estrogen sensitivity of the tumor could account for the rapid growth.
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Farrow GH, Ashikari H: Breast lesion in young girls.Surg Clin North Am 49:261–269, 1969.
James RH, Robert EG: Giant breast tumor the adolescent.Am J Surg 109:810–813, 1965.
Itou S, Sasa M, Numoto S: A case of juvenile fibroadenoma of the breast.Jpn J Breast Cancer 10:415418, 1995 (in Japanese with English abstract).
Haagensen CD: Diseases of the Breast, W. B. Saunders Co, Philadelphia and London, p235, 1956.
Lester J, Stout AP: Cystosarcoma phyllodes.Cancer 7: 335–353, 1954.
Lewis D, Geschickter CF: Gynecomastia, virginal hypertrophy, and fibroadenoma of the breast.Ann Surg 100:779–795, 1934.
Fisher W, Smith JW: Macromastia during puberty.Plast Reconstr Surg 47:445–451, 1971.
Sperling LS, Gold JJ: Use of an anti-estrogen after a reduction mammoplasty to prevent recurrence of virginal hypertrophy of breasts.Plast Reconstr Surg 52:439–442, 1973.
Mayl N, Vasconez LO, Jurkiewicz MZ: Treatment of macromastia in the actively enlarging breast.Plast Reconstr Surg 54:6–12, 1974.
Boyce SW, Hoffman PGJ, Mathes SJ: Recurrent macromastia after subcutaneous mastectomy.Ann Plast Surg 13:511–518, 1984.
Wolner-Hanssen P, Palmer B, Sjoberg NO,et al: Case report; Gigantomastia.Acta Obstet Gynecol Scand 60: 525–527, 1981.
Wise RJ: Treatment of breast hypertrophy.Clin Plast Surg 3:289–300, 1976.
Rao BR, Meryer JS, Fry CG: Most cystosarcoma phyllodes and fibroadenoma have progesterone receptor but lack estrogen receptor; Stromal localization of progesterone recepter.Cancer 47:2016–2021, 1981.
Morimoto T, Komaki K, Mori T,et al: Juvenile Gigantomastia; Report of a case.Jpn J Surg 23:260- 264, 1993.
Ryan RF, Pernoll ML: Virginal hypertrophy.Plast Reconstr Surg 75:737–742, 1985.
Furnas DW: Subcutaneous mastectomy for juvenile hypertrophy of the breast; Report of a case.Br J Plast Surg 35:367–370, 1982.
Castro CC: Subcutaneous mastectomy for gigantomastia in an adolescent girl.Plast Reconstr Surg 59: 575–578, 1977.
Sanuelov R, Siplovich L: Juvenile gigantomastia.J Pediatr Surg 23:1014–1015, 1988.
West KW, Frederick J, Rescorla LR,et al: Diagnosis and treatment of symptomatic masses in the pediatric population.J Pediatr Surg 30:182–187, 1995.
Okermann HA: Juvenile (cellular) adenofibromas, a clinicopathological study.J Pathol 9:730–736, 1985.
Nambian R, Kutty MK: Giant fibroadenoma (cystosarcoma phyllodes) in adolescent females; A clinicopathological study.Br J Surg 61:113–117, 1974.
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Tochika, N., Ogawa, Y., Kumon, M. et al. Rapid growing fibroadenoma in an adolescent. Breast Cancer 5, 321–324 (1998). https://doi.org/10.1007/BF02966715
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DOI: https://doi.org/10.1007/BF02966715