Summary
THE role of cholecystokinin (CCK) on the periodic pancreatic secretion and gallbladder contraction was studied in fasting conscious dogs. The bile pressure peak preceded the pancreatic protein peak by about 30 min. Its pressure at the peak was significantly higher than at the pancreatic peak, while pancreatic protein secretion at the bile peak was significantly lower than at its own peak. Plasma CCK levels at the gallbladder and pancreatic peaks were significantly higher than those at the upper gastrointestinal motor and secretory quiescent period. Levels at either peaks, however, did not differ.
Atropine abolished the periodic increase of pancreatic secretion, gallbladder contraction and plasma CCK. It is concluded that the inter-digestive CCK release is dependent on cholinergic nerves. It may modulate the action of the nerves on the pancreas and the gallbladder. Correlation between plasma CCK and pancreatic polypeptide was not significant.
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Magee, D.F., Murphy, R.F. & Naruse, S. Relationship of periodic pancreatic secretion and gallbladder contraction to plasma cholecystokinin in dogs. I.J.M.S. 157, 261–264 (1988). https://doi.org/10.1007/BF02948283
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DOI: https://doi.org/10.1007/BF02948283