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Disordered cellular immunity in type 1 diabetes of man and the BB rat

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References

  1. Rotter, J.I.; Rimoin, D.L.: Genetics; in Brownlee, Diabetes mellitus, vol. 1: etiology, hormone physiology, pp. 3–93 (Garland, New York 1981).

    Google Scholar 

  2. Volpe, R.: Monographs on endocrinology, vol. 20: Autoimmunity in the endocrine system (Springer, New York 1981).

    Google Scholar 

  3. Kahn, C.R.; Baird, K.L.; Flier, J.S.; Grunfeld, C.; Harmon, J.T.; Harrison, L.C.; Karlsson, F.A.; Kasuga, M.; King, G.L.; Lang, U.C.; Podskalny, J.M.; Obberghen, E.V.: Insulin receptors, receptor antibodies and the mechanism of insulin action. Recent Prog. Horm. Res.37: 477–533 (1981).

    PubMed  CAS  Google Scholar 

  4. Cahill, G.F., Jr.; McDevitt, H.O.: Insulin-dependent diabetes mellitus: the initial lesion. New Engl. J. Med.304: 1454–1465 (1981).

    PubMed  Google Scholar 

  5. Handwerger, B.S.; Fernandes, G.; Brown, D.M.: Immune and autoimmune aspects of diabetes mellitus. Human Pathol.11: 338–352 (1980).

    Article  CAS  Google Scholar 

  6. Selam, J.L.; Clot, J.; Andary, M.; Mirouze, J.: Circulating lymphocyte subpopulations in juvenile insulin-dependent diabetes. Diabetologia16: 35–40 (1979).

    Article  PubMed  CAS  Google Scholar 

  7. Ptak, W.; Hanczakowska, M.; Rozycka, R.; Rozycka, D.: Impaired antibody responses in alloxan diabetic mice. Clin. exp. Immunol.29: 140–146 (1977).

    PubMed  CAS  Google Scholar 

  8. Ptak, W.; Rewicka, M.; Kollat, M.: Development of specific suppressor cells in hypoinsulinaemic mice. Nature283: 199–200 (1980).

    Article  PubMed  CAS  Google Scholar 

  9. Ptak, W.; Rewicka, M.; Kollat, M.; Walicki, W.: Ease of induction of cells producing TNP-specific suppressor factor in hypoinsulinemic mice. Clin. Immunol. Immunopathol.19: 447–451 (1981).

    Article  PubMed  CAS  Google Scholar 

  10. Roth, M.D.; Barg, M.; Michalski, R.; Arquilla, E.R.: Cell-mediated immunity in chronically diabetic mice. Diabetes29: 825–829 (1980).

    PubMed  CAS  Google Scholar 

  11. Bersani, G.; Zanco, P.; Padovan, D.; Betterle, C.: Lymphocyte subpopulations in insulin-dependent diabetics with and without serum islet-cell autoan-tibodies. Diabetologia20: 47–50 (1981).

    Article  PubMed  CAS  Google Scholar 

  12. Jackson, R.; Rassi, N.; Crump, T.; Haynes, B.; Eisenbarth, G.S.: The BB diabetic rat. Profound T-cell lymphocytopenia. Diabetes30: 887–889 (1981).

    Article  PubMed  CAS  Google Scholar 

  13. Poussier, P.; Nakhooda, A.F.; Falk, J.A.; Lee, C; Marliss, E.B.: Lymphopenia and abnormal lymphocyte subsets in the ‘BB’ rat: relationship to the diabetic syndrome. Endocrinology110: 1825–1827 (1982).

    PubMed  CAS  Google Scholar 

  14. Elder, M.; MacLaren, N.: Immunoincompetence in the BB rat (Abstract). Diabetes31: suppl. 2, p. 48 (1982).

    Google Scholar 

  15. Nakhooda, A.F.; Like, A.A.; Chappel, C.I.; Murray, F.T.; Marliss, E.B.: The spontaneously diabetic Wistar rat. Metabolic and morphologic studies. Diabetes26: 100–112 (1976).

    Article  Google Scholar 

  16. Like, A.A.; Butler, L.; Williams, R.M.; Appel, M.C.; Weringer, E.J.; Rossini, A.A.: Spontaneous autoimmune diabetes mellitus in the BB rat. Diabetes31: suppl. 1. pp. 7–13 (1982).

    Article  PubMed  CAS  Google Scholar 

  17. Marliss, E.B.; Sima, A.A.F.; Nakhooda, A.F.: Spontaneous diabetes in the ‘BB’ Wistar rat; in Martin, Ehrlich, Holland, Etiology and pathogenesis of insulin dependent diabetes mellitus, pp. 251–274 (Raven Press, New York 1981).

    Google Scholar 

  18. Tannenbaum, G.S.; Colle, E.; Gurd, W.; Wana-maker, L.: Dynamic time-course studies of the spontaneously diabetic BB Wistar rat. I. Longitu- dinal profiles of plasma growth hormone, insulin, and glucose. Endocrinology109: 1872–1879 (1981).

    PubMed  CAS  Google Scholar 

  19. Tannenbaum, G.S.; Colle, E.; Wanamaker, L.; Gurd, W.; Goldman, H.; Seemayer, T.A.: Dynamic time-course studies of the spontaneously diabetic BB Wistar rat. II. Insulin-, glucagon-, and somatostatin-reactive cells in the pancreas. Endocrinology109: 1880–1887 (1981).

    Article  PubMed  CAS  Google Scholar 

  20. Nakhooda, A.F.; Like, A.A.; Chappel, C.I.; Wei, C.-N.; Marliss, E.B.: The spontaneously diabetic Wistar rat (the ‘BB’ rat). Studies prior to and during development of the overt syndrome. Diabetologia14: 199–207 (1978).

    Article  PubMed  CAS  Google Scholar 

  21. Rossini, A.A.; Williams, R.M.; Mordes, J.P.; Appel, M.C.; Like, A.A.: Spontaneous diabetes in the gnotobiotic BB/W rat. Diabetes28: 1031–1032 (1979).

    Article  PubMed  CAS  Google Scholar 

  22. Rossini, A.A.; Mordes, J.P.; Williams, R.M.; Like, A.A.: Expression of diabetes in Bio-Breeding/Worcester (BB/W) rats is not influenced by diet (Abstract). Diabetes30: suppl. 1, p. 93 (1981).

    Google Scholar 

  23. Elder, M.; McLaren, N.; Riley, W.; McConnell, T.: Gastric parietal cell and other autoantibodies in the BB rat. Diabetes31: 313–318 (1982).

    Article  PubMed  CAS  Google Scholar 

  24. Sternthal, E.; Like, A.A.; Sarantis, K.; Braverman, L.E.: Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy. Diabetes30: 1058–1061 (1981).

    Article  PubMed  CAS  Google Scholar 

  25. Eisenbarth, G.; Jackson, R.: Immunogenetics of polyglandular failure and related disease; in Farid, HLA in endocrine and metabolic disorders (Academic Press, New York 1981).

    Google Scholar 

  26. Dobersen, M.J.: Humoral autoimmunity in insulin-dependent (type I) diabetes mellitus. A current assessment. Surv. immunol. Res.1: 329–338 (1982).

    PubMed  CAS  Google Scholar 

  27. Dyrberg, T.; Nakhooda, A.F.; Baekkeskov, S.; Lernmark, A.; Poussier, P.; Marliss, E.B.: Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat. Diabetes31: 278–281 (1982).

    Article  PubMed  CAS  Google Scholar 

  28. Dyrberg, T.; Nakhooda, A.F.; Baekkeskov, S.; Poussier, P.; Marliss, E.B.; Lernmark, A.: Islet cell surface antibodies (ICSA) and lymphocyte antibodies (LA) in the spontaneously diabetic BB Wistar rat (Abstract). Diabetes31: suppl. 2, p. 19 (1982).

    Google Scholar 

  29. Naji, A.; Silvers, W.; Bellgrau, D.; Barker, C.: Spontaneous diabetes in rats: destruction of islets is prevented by immunological tolerance. Science213: 1390–1392 (1981).

    Article  PubMed  CAS  Google Scholar 

  30. Like. A.; Rossini, A.; Guberski, D.; Appel, M.: Spontaneous diabetes mellitus: reversal and prevention in the BB/W rat with antiserum to rat lymphocytes. Science206: 1421–1423 (1979).

    Article  PubMed  CAS  Google Scholar 

  31. Like, A.; Kislauskis, E.; Williams, R.; Rossini, A.: Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/W rat. Science216: 644–646(1982).

    Article  PubMed  CAS  Google Scholar 

  32. Naji, A.; Silvers, W.K.; Barker, C.F.: Islet transplantation in spontaneously diabetic rats. Transplant. Proc.13: 826–828 (1981).

    PubMed  CAS  Google Scholar 

  33. Kadison, P.: Jackson, R.; Rassi, N.; Haynes, B.; Jegasothy, B.; Eisenbarth, G.S.: The BB rat: selective W3/25 T cell lymphocytopenia and profound depression of mitogen responsiveness (Abstract). Clin. Res.30: 396 (1982).

    Google Scholar 

  34. Jackson, R.: Buse, J.B.; Eisenbarth, G.S.: Unpublished observations.

  35. Haynes, B.: Warren, R.; Buckley, R.; McClure, J.; Goldstein, A.; Eisenbarth, G.S.: Complex ganglio-sides as markers of thymic epithelium: demonstration of defects in thymic epithelium structure and ganglioside expression in severe combined immunodeficiency disease (Abstract). Clin. Res.30: 350 (1982).

    Google Scholar 

  36. Colle, E.; Guttmann, R.D.; Seemayer, T.: Spontaneous diabetes mellitus syndrome in the rat. J. exp. Med.154: 1237–1242 (1981).

    Article  PubMed  CAS  Google Scholar 

  37. Colle, E.; Guttmann, R.D.; Michel, F.; Seemayer, T.A.: Genetics of T lymphopenia in the syndrome of spontaneous diabetes mellitus in the rat (Abstract). Diabetes31: suppl. 2, p. 46 (1982).

    Google Scholar 

  38. LeCompte, P.M.: ‘Tnsulitis’ in early juvenile diabetes. Archs Path.66: 450–457 (1958).

    CAS  Google Scholar 

  39. Gepts, W.: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes14: 619–633 (1965).

    PubMed  CAS  Google Scholar 

  40. Eisenbarth, G.S.; Wilson, P.W.; Ward, F.; Buckley, C; Lebovitz. H.: The polyglandular failure syndrome: disease inheritance, HLA type, and immune function. Ann. intern. Med.91: 528–533 (1979).

    PubMed  CAS  Google Scholar 

  41. Nerup, J.; Andersen, O.O.; Bendixen, G.; Egeberg, J.; Poulsen, J.E.: Antipancreatic cellular hypersensitivity in diabetes mellitus. Diabetes20: 424–427 (1971).

    PubMed  CAS  Google Scholar 

  42. Nerup, J.; Andersen, O.O.; Bendixen, G.; Egeberg, J.; Poulsen, J.E.; Anti-pancreatic, cellular hyper- sensitivity in diabetes mellitus. Antigenic activity of fetal calf pancreas and correlation with clinical type of diabetes. Acta allerg.28: 223–230 (1973).

    CAS  Google Scholar 

  43. MacCuish, A.C.; Jordan, J.; Campbell, C.J.; Duncan, L.J.P.; Irvine, W.J.: Cell-mediated immunity to human pancreas in diabetes mellitus. Diabetes25:693–697(1974).

    Google Scholar 

  44. Nagaoka, K.; Sakurami, T.; Nabeya, N.; Imura, H.; Kuno, S.: The leucocyte migration inhibition test and subpopulations of peripheral lymphocytes in insulin-dependent diabetics. Endocr. jap.26: 89–95(1979).

    CAS  Google Scholar 

  45. Irvine, W.J.; MacCuish, A.C.; Campbell, C.J.; Duncan, L.J.P.: Organ-specific cell-mediated autoimmunity in diabetes mellitus. Acta endocr., suppl. 205, pp. 65–75 (1976).

    CAS  Google Scholar 

  46. Huang, S.-W.; MacLaren, N.K.: Insulin-dependent diabetes: a disease of autoaggression. Science192:64–66 (1976).

    Article  PubMed  CAS  Google Scholar 

  47. Scott, J.; Daniels, J.C.; Poffenbarger, P.L.: In vitro cell-mediated cytolysis of intact islets of Langerhans in a study of type I diabetics (Abstract). Diabetologia21: 78–79 (1981).

    Article  Google Scholar 

  48. Boitard, C; Debray-Sachs, M.; Pouplard, A.; Assan, R.; Hamburger, J.: Lymphocytes from diabetics suppress insulin release in vitro. Diabetologia21:41–46 (1981).

    PubMed  CAS  Google Scholar 

  49. Kaldany, A.; Hill, T.; Wentworth, S.; Brink, S.J.; Delia, J.A.; Clouse, M.; Soeldner, J.S.: Trapping of peripheral blood lymphocytes in the pancreas of patients with acute-onset insulin-dependent diabetes mellitus. Diabetes31: 463–466 (1982).

    Article  PubMed  CAS  Google Scholar 

  50. Buschard, K.; Madsbad, S.; Rygaard, J.: Passive transfer of diabetes mellitus from man to mouse. Lanceti: 908–910 (1978).

    Article  Google Scholar 

  51. Neufeld, M.; McLaughlin, J.; MacLaren, N.K.; Rosenbloon, E.; Donnelly, W.: Failure to transfer diabetes mellitus from man to mouse. New Engl. J. Med.301: 665 (1979).

    PubMed  CAS  Google Scholar 

  52. Lipsick, J.; Beattie, G.; Osier, A.G.; Kaplan, N.O.: Letter to the editor. Lanceti: 1290–1291 (1979).

    Article  Google Scholar 

  53. Thurneyssen, O.; Jansen, F.K.; Vialettes, B.; Vague, P.; Selam, J.L.; Mirouze, J.: Letter to the editor. Lanceti: 1291–1292 (1979).

    Google Scholar 

  54. Serra, A.S.; Farndon, J.R.; Shenton, B.K.; Johnston, I.D.A.: Letter to the editor. Lanceti: 1292 (1979).

    Google Scholar 

  55. Buschard, K.; Rygaard, J.; Madsbad, S.: Letter to the editor. Lancetii: 303 (1979).

    Article  Google Scholar 

  56. Beattie, G.; Lannom, R.; Lipsick, J.; Kaplan, N.O.; Osier, A.G.: Streptozotocin-induced diabetes in athymic and conventional BALB/c mice. Diabetes29: 146–150 (1980).

    Article  PubMed  CAS  Google Scholar 

  57. Buschard, K.; Rygaard, J.: Passive transfer of streptozotocin induced diabetes mellitus with spleen cells. Acta pathol. microbiol. scand., C, Immunol.85: 469–472 (1977).

    Google Scholar 

  58. Kiesel, U.; Freytag, G.; Biener, J.; Kolb, H.: Transfer of experimental autoimmune insulitis by spleen cells in mice. Diabetologia19: 516–520 (1980).

    Article  PubMed  CAS  Google Scholar 

  59. Paik, S.-G.; Fleischer, N.; Shin, S.-L.: Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes. Proc. natn. Acad. Sci. USA77: 6129–6133 (1980).

    Article  CAS  Google Scholar 

  60. Buschard. K.; Rygaard, J.: T-lymphocytes transfer streptozotocin induced diabetes mellitus in mice. Acta pathol. microbiol. scand., C, Immunol.86: 277–282 (1978).

    Google Scholar 

  61. Rossini. A.A.; Williams, R.M.; Appel, M.C.; Like, A.A.: Complete protection from low-dose streptozotocin-induced diabetes in mice. Nature276: 182–184 (1978).

    Article  PubMed  CAS  Google Scholar 

  62. Buschard, K.; Rygaard, J.; Lund, E.: The inability of a diabetogenic virus to induce diabetes mellitus in athymic (nude) mice. Acta pathol. microbiol. scand.. C Immunol.84: 299–303 (1976).

    CAS  Google Scholar 

  63. Paik, S.-G.; Yoon, J.-W.; Shin, S.: Induction of diabetes in mice by EMC virus: host T cells are not required (Abstract). Diabetes31: suppl. 2, p. 66 (1982).

    Google Scholar 

  64. Jansen. F.K.: Muntefering, H.; Schmidt, W.A.K.: Virus induced diabetes and the immune system. Diabetologia13: 545–549 (1977).

    Article  PubMed  CAS  Google Scholar 

  65. Onodera, T.; Ray, U.R.; Melez, K.A.; Suzuki, H.; Toniolo, A.; Notkins, A.L.: Virus-induced diabetes mellitus: autoimmunity and polyendocrine disease prevented by immunosuppression. Nature297:66–68 (1982).

    Article  PubMed  CAS  Google Scholar 

  66. Ambinder, J.M.; Chiorazzi, N.; Gibofsky, A.; Fotino, M.; Kunkel. H.G.: Special characteristics of cellular immune function in normal individuals of the HLA-DR3 type. Clin. Immunol. Immunopathol.23: 269–274 (1982).

    Article  PubMed  CAS  Google Scholar 

  67. Jackson, R.A.; Morris, M.A.; Haynes, B.F.; Eisen-barth, G.S.: Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus. New Engl. J. Med.306: 785–788 (1982).

    PubMed  CAS  Google Scholar 

  68. Pozzilli, P.: Sensi, M.; Gorsuch, A.; Bottazzo, G.F.; Cudworth, A.G.: Evidence for raised K-cell levels in type I diabetes. Lancetii: 173–175 (1979).

    Article  Google Scholar 

  69. Pozzilli, P.; Sensi, M.; Dean, B.; Gorsuch, A.; Cudworth, A.: The importance of measuring Fc+ (killer) cells in insulin-dependent (type I) diabetes. Acta diabet. lat.17: 119–122 (1980).

    Article  CAS  Google Scholar 

  70. Sensi, M; Pozzilli, P.; Gorsuch, A.N.; Bottazzo, G.F.; Cudworth, A.G.: Increased killer cell activity in insulin dependent (type I) diabetes mellitus. Diabetologia20: 106–109 (1981).

    Article  PubMed  CAS  Google Scholar 

  71. Sensi, M.; Pozzilli, P.; Cudworth, A.G.: Antibody-dependent and natural killer cytotoxicity in type I diabetes. Acta diabet. lat.18: 339–344 (1981).

    Article  CAS  Google Scholar 

  72. Ludwig, H.; Schernthaner, G.; Kraft, D.; Scheiner, O.; Mayr, W.R.: Antibody-dependent killer-cell function in insulin-dependent diabetes mellitus. J. endocrinol. Invest.3: 39–44 (1980).

    PubMed  CAS  Google Scholar 

  73. Buschard, K.; Madsbad, S.; Rygaard, J.: Depressed suppressor cell activity in patients with newly diagnosed insulin-dependent diabetes mellitus. Clin. exp. Immunol.41: 25–32 (1980).

    PubMed  CAS  Google Scholar 

  74. Fairchild, R.S.; Kynder, J.L.; Abdou, N.I.: Specific immunoregulation abnormality in insulin-dependent diabetes mellitus. J. Lab. clin. Med.99: 175–186 (1982).

    PubMed  CAS  Google Scholar 

  75. Galluzzo, A.; Giordano, C; Sparacino, G.; Bom-piani, G.D.; McNally, J.; Bottazzo, G.F.: Studies on suppressor cell function in the families of patients with insulin dependent diabetes mellitus (Abstract). Diabetologia21: 82 (1981).

    Google Scholar 

  76. Jaworski, M.A.; Guttman, R.D.; Colle, E.: Familial abnormalities of suppressor T cell activity in juvenile-onset insulin-dependent diabetes mellitus (Abstract). Clin. Res.30: 395 (1982).

    Google Scholar 

  77. Buschard, K.; Madsbad, S.; Rygaard, J.: Suppressor cell activity and beta-cell function in insulin-dependent diabetes. Acta pathol. microbiol. scand., C, Immunol.90: 53–57 (1982).

    CAS  Google Scholar 

  78. Buschard, K.; Madsbad, S.; Krarup, T.; Rygaard, J.: Glycaemic control and suppressor cell activity in patients with insulin-dependent diabetes mellitus. Clin. exp. Immunol.48: 189–195 (1982).

    PubMed  CAS  Google Scholar 

  79. Lederman, M.M.; Ellner, J.J.; Rodman, H.M.: Defective suppressor cell generation in juvenile onset diabetes. J. Immun.127: 2051–2055 (1981).

    PubMed  CAS  Google Scholar 

  80. Serjeantson, S.; Theophilus, J.; Zimmet, P.; Court, J.; Crossley, J.R.; Elliott, R.B.: Lymphocytotoxic antibodies and histocompatibility antigens in juvenile-onset diabetes mellitus. Diabetes30: 26–29 (1981).

    Article  PubMed  CAS  Google Scholar 

  81. Sakane, T.; Steinberg, A.D.; Reeves, J.P.; Green, I.: Studies of immune functions of patients with systemic lupus erythematosus. J. clin. Invest.64: 1260–1269(1978).

    Article  Google Scholar 

  82. Srikanta, S.; Ganda, O.; Soeldner, S.; Eisenbarth, G.: Unpublished observations.

  83. Gorsuch, A.N.; Spencer, K.M.; Lister, J.; McNally, J.M.; Dean, B.M.; Bottazzo, G.F.; Cudworth, A.G.: Evidence of a long prediabetic period in type I (insulin-dependent) diabetes mellitus. Lancetii: 1363–1365 (1981).

    Article  Google Scholar 

  84. Elliott, R.B.; Crossley, J.R.; Berryman, C.C.; James, A.G.: Partial preservation of pancreatic β-cell function in children with diabetes. Lancetii: 1–4(1981).

    Article  Google Scholar 

  85. Deckert, T., Poulson, J.; Larsen, M.: The prognosis of insulin dependent diabetes mellitus and the importance of supervision. Acta med. scand., suppl. 624, pp. 48–53 (1979).

    CAS  Google Scholar 

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  1. Research Division, Joslin Diabetes Center, Inc., 1 Joslin Place, 02215, Boston, MA, (USA)

    John B. Buse, Richard F. Rowley & George S. Eisenbarth

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Buse, J.B., Rowley, R.F. & Eisenbarth, G.S. Disordered cellular immunity in type 1 diabetes of man and the BB rat. Surv. immunol. Res. 1, 339–351 (1982). https://doi.org/10.1007/BF02918546

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