Abstract
Background Guidelines for the prevention of corticosteroid-induced osteoporosis (CIO) have been widely published. There are no guidelines on the use of gastro-protectants with corticosteroids (CS).
Aims To determine whether patients receiving CS therapy are evaluated and treated for osteoporosis risk, how management varied by steroid dose and diagnosis, and how many patients received gastro-protection.
Methods A retrospective audit of 4,350 patients presenting to four medical specialities.
Results One hundred and fifty-one patients prescribed CS were identified. Indications for CS therapy included renal transplantation (32%) and asthma/respiratory diseases (23%), inflammatory arthritis/vasculitis (32%) and inflammatory bowel disease/auto-immune hepatitis/other (13%). Risk of osteoporosis was mentioned in 13% of charts. The prescription rates for bone protection agents varied from 69% to 4% according to the medical speciality attended. Gastro-protectants were prescribed for 44% of patients.
Conclusion There are large variations among medical specialties both in the prescription of gastro-protectant agents and in the use of measures to prevent CIO. Simpler guidelines could facilitate rational prescribing in these patients.
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References
Tobias JH. Management of steroid-induced osteoporosis: what is the current state of play? Rheumatology (Oxford) 1999; 38 (3): 198–201.
Goldstein MH, Fallon JJ, Harning R. Chronic glucocorticoid therapyinduced osteoporosis in patients with obstructive lung disease.Chest 1999; 116: 1733–49.
Rosen HN, Rosenblatt M. Glucocorticoids and osteoporosis: pathogenesis and clinical features, In UpToDate Rose BD (Ed), UpToDate, Wellesley, MA 2001.
Writing group for the Bone and Tooth Society and Royal College of Physicians. Glucocorticoid-induced Osteoporosis: guidelines for the prevention and treatment. London: Royal College of Physicians. December 2002.
National Osteoporosis Foundation Physician’s guide to prevention and treatment of osteoporosis. November 1998.
Lenore, Buckley et al. Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis, 2001 Update, American College of Rheumatology Ad Hoc Committee on Glucocorticoid- Induced Osteoporosis.A rthritis Rheum 2001; 44 (7): 1496–503.
Reid DM. Editorial corticosteroid-induced osteoporosis: guidelines for prevention. Are they useful?Br J Rheumatol 1997; 36: 1035–7.
Walsh LJ, Wong CA, Pringle M, Tattersfield AE. Use of oral corticosteroids in the community and prevention of secondary osteoporosis: a cross sectional study.BMJ 1996; 313: 344–46.
Solomon DH, Katz JN, Jacobs JP et al. Management of glucocorticoid-induced osteoporosis in patients with rheumatoid arthritis: rates and predictors of care in an academic rheumatology practice.A rthritis Rheum 2002; 46 (12): 3136–42.
Messer J, Reitman D, Sacks HS et al. Association of adrenocorticosteroid therapy and peptic ulcer disease.N Engl J Med 1983; 309 (l): 21–4.
Pecora PG, Kaplan B. Corticosteroids and ulcers: is there an association?Ann Pharmacother 1996; 30(7-8): 870–2.
Bell R, Carr A, Thompson P. Managing corticosteroid induced osteoporosis in medical outpatients.J R Coll Physicians Lond, March 1, 1997; 31 (2): 158–61.
Van Staa TP. Use of oral corticosteroids in the United Kingdom.Q J Med 93: 105–11.
Scott EM, Gaywood I, Scott BB for the British society of gastroenterology. Guidelines for osteoporosis in coeliac disease and inflammatory bowel diseaseGut 2000; 46(suppl l): il-i8.
Kasiske BT et al. Recommendations for the surveillance of renal transplant recipients.J Am Soc Nephrol 1 LS 2000: 1–86.
Gudbjornsson B, Juliusson UI, Gudjonsson FV. Extended report: Prevalence of long term steroid treatment and the frequency of decision making to prevent steroid induced osteoporosis in daily clinical practice.Ann Rheum Dis 2002; 61: 32–6.
Hart SR, Green B. Osteoporosis prophylaxis during corticosteroid treatment: failure to prescribe.Postgrad Med J 2002; 78: 242–43.
Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of oestrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomised controlled trial.JAMA 2002; 888: 321–33.
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Ryan, J., Morgan, R., Lavin, P. et al. Current management of corticosteroid-induced osteoporosis: Variations in awareness and management. Ir J Med Sci 173, 20–22 (2004). https://doi.org/10.1007/BF02914518
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DOI: https://doi.org/10.1007/BF02914518