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Role of proteoglycans in tumor progression

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Pathology & Oncology Research

Abstract

Data is now starting to accumulate on the differential expression of PGs in tumor cells of various invasive/metastatic potential. This is not so surprising if one considers the key functions that PGs play in the regulation of cell proliferation, adhesion and motility. However, characterization of PG expression in individual tumor types still awaits further detailed studies. Data on melanomas clearly indicate that PG phenotype is both specific and also promiscuous in a sense that ectopic expression of certain tissue specific PGs can occur in various tumors. Expression of a metastatic phenotype-specific splice variants of CD44 provides an example for the possible marker-function of PG. This also raises the hope that some PGs could be used as diagnostic/prognostic tools in pathology or even as a therapeutic targets against tumor dissemination. On the other hand, specific glycanation inhibitors may also be used for the modulation of tumor PG exist and the invasive phenotype.

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Abbreviations

CS:

chondroitin sulphate

CSPG:

chondroitin sulphate proteoglycan

DS:

dermatan sulphate

DSPG:

dermatan sulphate proteoglycante]

ECM:

extracellular matrixte]

FGF:

fibroblast, growth factor

GAG:

glycosaminoglycan

galNac:

N-acetylgalactosamine

glcA:

glucosamine

glcNac:

N-acetyl-glucosamine

glcUA:

uronic acid

glcIA:

iduronic acid

HA:

hylauronic acid

HBP:

heparin-binding protein

HCGF:

hepatocyte growth factor

HS:

heparan sulphate

HSPG:

heparan sulphate proteoglycan

IL:

interleukin

MAA:

melanoma-associated antigen

PG:

proteoglycan

TGF:

transforming growth factor

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Authors and Affiliations

  1. 1st Institute of Pathology and Experimental Cancer Research, Semmelweis University of Medicine, Üllői út 26, 1085, Budapest, Hungary

    Jósef Timár, András Jeney, Ilona Kovalszky & László Kopper

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  1. Jósef Timár
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  2. András Jeney
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  3. Ilona Kovalszky
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  4. László Kopper
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This work received the 1994’ Huzella Memorial Award of the Semmelweis University of Medicine;and was supported by Hungarian National Science Foundation (OTKA) T13128 (J.T.). 2622B (L.K.) and 6070 (A.J.).

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Timár, J., Jeney, A., Kovalszky, I. et al. Role of proteoglycans in tumor progression. Pathol. Oncol. Res. 1, 85–93 (1995). https://doi.org/10.1007/BF02893590

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