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Interleukin-1α (IL-1α), IL-1β, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-β1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors

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Molecular and Chemical Neuropathology

Abstract

Interleukin-1α (IL-1α), IL-1β, interleukin-1 receptor type I (IL-1RI, signaling receptor), and IL-1 receptor antagonist (IL-1Ra, endogenous inhibitor) are pivotal components of the IL-1 system. IL-1 and other cytokines induced by IL-1, such as TGF-β1, may participate in the growth of various tumor cells. In children, primary nervous system tumors represent the most common solid malignancy. We investigated the levels of IL-1α, IL-1β, IL-1RI, IL-1Ra, and TGF-β1 mRNAs in pediatric astrocytomas (n=19), ependymomas (n=13), and primitive neuroectodermal tumors (n=22) using sensitive and specific RNase protection assays. The data show a significant distinct cytokine mRNA profile among brain tumor types. Pilocytic, nonpilocytic, and anaplastic astrocytomas have significant increased levels of IL-1β, IL-1RI, and TGF-β1 mRNAs, but low levels of IL-1Ra mRNA; this may have implications for an IL-1β feedback system and IL-1β↔TGF-β1 interactions in astrocytomas. Ependymomas show increased levels of IL-1α and IL-1β mRNAs associated with low levels of IL-1Ra mRNA; primitive neuroectodermal tumors do not exhibit increased levels of any cytokine component examined. The data also suggest that a dysregulation of the balance between stimulatory and inhibitory cytokines may be involved in the growth and development of brain tumors via autocrine/paracrine mechanisms.

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Authors and Affiliations

  1. Division of Molecular Biology, School of Life and Health Sciences, University of Delaware, 19716-2590, Newark, DE

    Sergey E. Ilyin & Carlos R. Plata-Salamán

  2. Department of Pathology, Childrens Hospital of Los Angeles, CA

    Ignacio González-Gómez & Floyd H. Gilles

Authors
  1. Sergey E. Ilyin
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  2. Ignacio González-Gómez
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  3. Floyd H. Gilles
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  4. Carlos R. Plata-Salamán
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Correspondence to Carlos R. Plata-Salamán.

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Ilyin, S.E., González-Gómez, I., Gilles, F.H. et al. Interleukin-1α (IL-1α), IL-1β, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-β1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors. Molecular and Chemical Neuropathology 33, 125–137 (1998). https://doi.org/10.1007/BF02870186

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  • DOI: https://doi.org/10.1007/BF02870186

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