Skip to main content
SpringerLink
Log in

Antioxidant effect ofPhyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats

  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Post-treatment of the indomethacin induced ulcerated rats at the optimal dose of 100 mg/kg body-wt. orally for 7 consecutive days with the lyophilized aqueous extract of the fruits ofPhyllanthus emblica L. syn.Emblica officinalis Gaertn. (Euphorbiaceae) exhibited highly significant (p<0.001) enhancement of secretion of catalase, reduced glutathione and decrease in malonyldialdehyde (MDA). Furthermore, the gross morphological observation and highly significant (p<0.001) decrease of ulcer index (81.43%) indicated healing effect of the extract on gastric ulcer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Satyavati, G.V., Raina, M. K. & Sharma, M., (1976)Medicinal Plants of India, Vol. 1 (Indian Council of Medical Research, New Delhi) 377.

    Google Scholar 

  2. Sharma, P.V., (1978)Dravyaguna Vijnana (Chaukhambha Sanskrit Sansthan, Varanasi).

    Google Scholar 

  3. Chatterjee, A. & Pakrashi, S. C., (1994)The Treatise on Indian Medicinal Plants, Vol. III (Publication and information Directorate, CSIR, New Delhi) 33–35.

    Google Scholar 

  4. Nadkarni, K. M., (1976),Indian Materia Medica, (Populat Prakashan, Bombay), 480.

    Google Scholar 

  5. Rao, C. H. V., Sairam, K., Agarwal, V.K., Joshi, V.K. & Goel, R.K. (2000), Effect ofPhyllanthus emblica Linn on gastric ulceration and secretionInd. J. Pharmacol., 32, 81–87.

    Google Scholar 

  6. Maulik, C Kagan, V E., Pakrashi S Maulik N & Das D K (1996) Extract of some Indian Plants with potent antioxidant properties. In:Proceeding of International Symposium on Natural Antioxidants: Mechanism and Health effects, edited by Packr L, Traner M G & Xin W, Beijing, China, 20–24 June, 1995, (AOCS Press, Chicago), 92–98.

    Google Scholar 

  7. Maulik G, Maulik N, Bhandari V, Kagan V E, Pakrashi S & Das D K (1997), Evaluation of antioxidant effectiveness of a few herbal plants,Free Rad. Res. 27, 221–228.

    Article  CAS  Google Scholar 

  8. Bandyopadhyay S K, Pakrashi S C & Pakrashi A (1999), The role of antioxidant activity ofPhyllanthus emblica fruits on prevention from indomethacin induced gastric ulcerJ. Ethnopharmacol., 70, 171–176.

    Article  Google Scholar 

  9. Walsh A, (1995), Application of atomic absorption spectra of chemical analysis,Spectrochim Acta, 7, 171–176.

    Google Scholar 

  10. Ahmad R, Moutairy A L, Mahammad T (1996), Effect of vitamin-E and selenium on hypothermic restraint stress and chemically induced ulcers,Digest Dis & Sci, 41, 1165–1169.

    Article  Google Scholar 

  11. Shay H, Karmarow S A, Fels S S, Meranze D, Gruenstein M & Siplet H, (1945), A simple method for the uniform production of gastric ulceration in the ratGasroenterol 5 43–45.

    Google Scholar 

  12. Lowry O H, Rosenbrough N S, Farr A L & Randall RJ (1951), Protein measurement with folin phenol,J. Biol. Chem., 193, 265–275.

    PubMed  CAS  Google Scholar 

  13. Esterbaner H & Cheeseman K. (1990), Determination of aldehydic lipid peroxidation products. Malonaldehyde and 4-hydroxynonal,Methods of Enzymology, 186, 407–421.

    Google Scholar 

  14. Lück H, Catalase (1965) In: Bergmeyer H U inMethods of Enzymatic Analysis (Academic Press London), p. 855–888.

    Google Scholar 

  15. Ellaman G L, (1959), Tissue sulfhydryl groups,arch Biochem Biophys, 82, 70–72.

    Article  Google Scholar 

  16. Yoshikawa T, Nioto Y, Tanigawa T, Yoneta T & Kondo M, (1991), The antioxidant properties of a novel zinc-carnosine chelate compound, N-(3-aminopropionyl)-L-histidinato-zincBiochem Biophys Acta, 1115, 15–22.

    PubMed  CAS  Google Scholar 

  17. Comporti M (1993), Biology of disease, lipid peroxidation and cellular damage in toxic liver injury,Lab Invest, 52, 599–623

    Google Scholar 

  18. Olsen C E, (1988). Glutathione modulates toxic oxygen metabolites injury of canine chief cell in primary culture,Amer J Physiol, 254, 649–656.

    Google Scholar 

  19. Mondal S, Das D N, De K, Ray K, Ray G, Chaudhuri S B, Sahana C C, Chaudhuri M K, (1993),Ociumum sanctum Linn-a study on gastric ulceration in rats.Ind. J. Physiol pharmacol 37(1), 1991–92.

    Google Scholar 

  20. Majumder B, Roychoudhuri S, Ray A, Bandyopadhyay S K (2002). Potent antiulcergenic activity of ethanol extract of leaf ofPiper betle Linn by antioxidative mechanism.Ind. J. Clin Biochem. 17(1), 49–57.

    Article  Google Scholar 

  21. Yahya MA Al, Rafatullah S, Ageel A M, Parmar N S, Tasriqq M (1989) Gastrocytoprotective effect of gingerZingiber afficinale Rosc in albino rats.Am J. Clin Med 17, 51–56

    Article  Google Scholar 

  22. Ray A and Bandyopadhyay S K (1998) Studies on Indian Traditional Medicine,Picrorhiza Kurrooa (Katuki) and peptic ulcer. Bom. Hosp. J. 40(3), 374–381.

    Google Scholar 

  23. Ligumuski M, Sestieri M, Okon E & Einsburg I, (1995), Antioxidants inhibit ethanol-induced gastric ulcer in the rat. Role of manganese, glycine and carotene,Scand J Gastroentrol 30, 854–860.

    Article  Google Scholar 

  24. Yoshikawa T, Nioto Y, Kishi A, Tomii T, Kaneko T, Linuma S, Ichikawa H, Yasuda M, Takahashi S & Kondo M, (1993), Role of active oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in ratsGut, 34, 732–737.

    Article  PubMed  CAS  Google Scholar 

  25. Bandyopadhyay B and Bandyopadhyay S K (1997). Protective effect of zinc gluconate on chemically induced gastric ulcerInd J. Med. Res. 106, 27–32.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, Indian Institute of Chemical Biology, 244B, Acharya J. C. Bose Road, 700 032, Kolkata

    Anita Pakrashi

  2. University College of Medicine Dr. B. C. Roy Post Graduate Institute of Basic Medical Sciences, Calcutta University, 244B, Acharya J.C. Bose Road, 700 020, Kolkata

    Srikanta Pandit, Sandip K. Bandyopadhyay & Satyesh C. Pakrashi

Authors
  1. Anita Pakrashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Srikanta Pandit
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sandip K. Bandyopadhyay
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Satyesh C. Pakrashi
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pakrashi, A., Pandit, S., Bandyopadhyay, S.K. et al. Antioxidant effect ofPhyllanthus emblica fruits on healing of indomethacin induced gastric ulcer in rats. Indian J Clin Biochem 18, 15–21 (2003). https://doi.org/10.1007/BF02867660

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02867660

Key words

Search

Navigation