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Effects of hemodialysis on myocardial performance index

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Abstract

The myocardial performance index (MPI) reflects global ventricular function. Chronic hypervolemia and uremia may negatively affect the myocardium of both ventricles. The aims of this study were to investigate how chronic renal failure (CRF) affects biventricular MPI and to determine whether preload reduction by hemodialysis (HD) affects left ventricular MPI (LVMPI) and right ventricular MPI (RVMPI) in CRF. Twenty-one patients with CRF (group 1) were examined 1 hour before and 1 hour after an HD session and 1 7 healthy control patients (group 2) were examined once by echocardiography. The MPI for each ventricle was calculated as the sum of isovolumic time intervals divided by the ejection time. Before HD, the LVMPI of group 1 was similar to that in group 2 (P≫.05), but the RVMPI of group 1 was significantly higher (P=.007). After the HD session, LVMPI and RVMPI remained unchanged (P>.05 for both). The LVMPI and RVMPI were not correlated either before or after HD in group 1 (P>.05 for both), whereas they were correlated in group 2 (r= 0.671, P=.003). Chronic renal failure causes isolated RV dysfunction, as reflected by increased RVMPI values. Preload reduction by HD does not affect LVMPI or RVMPI. Patients with CRF also do not exhibit the correlation of LVMPI and RVMPI that is observed in healthy individuals.

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Authors and Affiliations

  1. Department of Cardiology, Baskent University Faculty of Medicine, Ankara, Turkey

    Melek Ulucam MD (Asst Prof), Aylin Yildirir FESC (Assoc Prof), Haldun Muderrisoglu FESC (Prof), Mehmet Emin Korkmaz FESC (Prof), Bulent Ozin (Assoc Prof) & Egemen Tayfun MD

  2. Department of Nephrology, Baskent University Faculty of Medicine, Ankara, Turkey

    Ulkem Yakupoglu MD & Nurhan Ozdemir (Prof)

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  1. Melek Ulucam MD
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  2. Aylin Yildirir FESC
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  3. Haldun Muderrisoglu FESC
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  4. Ulkem Yakupoglu MD
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  5. Mehmet Emin Korkmaz FESC
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  6. Nurhan Ozdemir
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  7. Bulent Ozin
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  8. Egemen Tayfun MD
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Ulucam, M., Yildirir, A., Muderrisoglu, H. et al. Effects of hemodialysis on myocardial performance index. Adv Therapy 21, 96–106 (2004). https://doi.org/10.1007/BF02850337

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