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Fatal lactic acidosis due to leukemic transformation in a patient with non-Hodgkin’s lymphoma: Case report

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Abstract

Lactic acidosis (LA) associated with hematologic malignancies is uncommon, lifethreatening, and generally occurs in adults. Its pathogenesis is poorly understood. This is a case report of LA due to leukemic transformation that occurred in a patient with non-Hodgkin’s lymphoma (NHL). A 24-year-old man with NHL was admitted to the hospital with dyspnea. Venous blood gas analysis revealed metabolic acidosis (pH 7.05; HCO3 6 mEq/L; BE 22 mmol/L; anion gap 28 mEq/L); the patient had an elevated plasma lactate concentration (12 mmol/L) and low glucose concentration (38 mg/dL). There was no reason other than leukemia—such as infection, circulatory failure, or drug use—for the development of severe LA. This case report shows that in patients with NHL, leukemic transformation may give rise to LA.

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Authors and Affiliations

  1. Division of Nephrology, Turkey

    Ekrem Dogan MD, Reha Erkoc MD (Assoc Prof) & Hayriye Sayarlioglu MD (Asst Prof)

  2. Division of Medical Oncology, Yüzüncü Yil University, Van, Turkey

    Suleyman Alici (Assoc Prof)

  3. Department of Internal Medicine Division of Hematology, Yüzüncü Yil University, Van, Turkey

    Imdat Dilek MD (Prof)

  4. Department of Infectious Diseases and Clinical Microbiology, Yüzüncü Yil University, Van, Turkey

    Ozlem Alici MD

Authors
  1. Ekrem Dogan MD
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  2. Reha Erkoc MD
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  3. Hayriye Sayarlioglu MD
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  4. Suleyman Alici
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  5. Imdat Dilek MD
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  6. Ozlem Alici MD
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Dogan, E., Erkoc, R., Sayarlioglu, H. et al. Fatal lactic acidosis due to leukemic transformation in a patient with non-Hodgkin’s lymphoma: Case report. Adv Therapy 22, 443–446 (2005). https://doi.org/10.1007/BF02849863

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  • DOI: https://doi.org/10.1007/BF02849863

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