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Application of particle-induced X-ray emission to research in biology and medicine

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Abstract

The analytical technique of particle-induced X-ray emission (PIXE) is described, and recent applications to problems in biomedical research are surveyed.

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References

  1. W. Mertz,Science 213, 1332 (1981).

    Article  PubMed  CAS  Google Scholar 

  2. W. Mertz,Nutr. Today; (a) vol.18, no. 2, p. 6 (1983); (b) ibid W. Mertz,Nutr. Today,18, no. 5, p. 26 (1983); (c) ibid W. Mertz,Nutr. Today,19, no. 1, p. 22 (1984).

    Article  Google Scholar 

  3. G. V. Iyengar, W. E. Kollmer, and H. J. M. Bowen,The Elemental Composition of Human Tissues, and Body Fluids Verlag Chemie, Weinheim, 1978.

    Google Scholar 

  4. G. V. Iyengar,Sci. Total Environ. 38, 125 (1984) and these proceedings.

    Article  PubMed  CAS  Google Scholar 

  5. B. Martin, ed., Particle-induced X-ray, emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984).

  6. S. A. E. Johnasson and T. B. Johansson,Nucl. Instr. Meth. 137, 473 (1976).

    Article  Google Scholar 

  7. T. A. Cahill,Ann. Rev. Nucl. Part. Sci. 30, 211 (1980).

    Article  CAS  Google Scholar 

  8. M. R. Khan and D. Crumpton,CRC Critical Rev. Anal. Chem. 11, 103 (1981).

    Article  CAS  Google Scholar 

  9. I. V. Mitchell and K. M. Barfoot,Nucl. Sci. Appl. 1, 99 (1981).

    CAS  Google Scholar 

  10. S. Monaro and R. Lecomte,Int. J. Nucl. Med. Biol. 8, 1 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. R. D. Vis, C. C. A. H. Van der Stap, and A. J. J. Bos, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 319.

  12. N. F. Mangelson and N. W. Hill,Nucl. Instr. Meth. 181, 243 (1981).

    Article  CAS  Google Scholar 

  13. G. Deconnick, ibid191, 543 (1981).

    Article  Google Scholar 

  14. J. L. Campbell,IEEE Trans. Nucl. Sci. NS-26, 1363 (1979); andNeurotoxicology 4, (no. 3), 1 (1983).

    Google Scholar 

  15. B. Kratochvil, D. Wallace, and J. K. Taylor,Anal. Chem. 56, 113R (1984).

    Article  Google Scholar 

  16. J. Versieck, inCRC Critical Reviews in Clinical Laboratory Sciences, vol. 22 (No. 2), CRC Press, Boca Raton, FL, 1985, pp. 97–184;Trace Elem. Med. 1, 2 (1984); and these proceedings.

    Google Scholar 

  17. J. R. Chen,Nucl. Instr. Meth. 181, 337 (1981).

    Article  Google Scholar 

  18. R. Lecomte, P. Paradis, S. Monaro, M. Barrette, G. Lamoureux, W. A. Menard,Int. J. Nucl. Med. Biol. 10, 35 (1983).

    Article  PubMed  CAS  Google Scholar 

  19. M. Simonoff, Y. Llabador, G. N Simonoff, M. R. Boisseau, and M. F. Lorient Roudaut,J. Radioanal. Nucl. Chem. 94, 297 (1985).

    Article  CAS  Google Scholar 

  20. T. Juswigg, R. Batres, N. W. Solomons, O. Pineda, and D. B. Milne,Am. J. Clin. Nutr. 36, 354 (1982).

    PubMed  CAS  Google Scholar 

  21. E. Johansson, U. Lindh, and E. Landstrom,Biol. Trace Elem. Res. 5, 433 (1983).

    Article  CAS  Google Scholar 

  22. J. L. Campbell and J. A. Cookson, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 185.

  23. H. A. Van Rinsvelt, R. W. Hurd, J. W. A. Kondoro, J. M. Andres, J. P. Mickle, B. J. Wilder, W. Maenhaut, and L. De Reu, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984) p. 377.

  24. A. J. J. Bos, C. C. A. H. van der Stap, V. Valkovic, R. D. Vis, and H. Verheul,Sci. Total Environ. 42, 157 (1985).

    Article  PubMed  CAS  Google Scholar 

  25. U. Lindh, E. Johansson, and L. Gille, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 631.

  26. G. W. Grime, F. Watt, S. Mann, C. C. Perry, J. Webb, and R. J. P. Williams,Trends Biochem. Sci. 10, (no. 1), 6, (1985).

    Article  CAS  Google Scholar 

  27. S. B. Doty, K. W. Jones, H. W. Kraner, R. E. Shroy, and A. L. Hanson,Nucl. Instr. Meth. 181, 159 (1981).

    Article  CAS  Google Scholar 

  28. E. T. Williams, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 211.

  29. A. H. Khan, Dhaka, personal communication, 1985.

  30. S. A. Tarafdar, A. H. Khan, and M. Rahman,Agric. Biol. Chem. 49, 201 (1985).

    CAS  Google Scholar 

  31. Hadi, M. Ali, S. K. Biswas, M. M. Islam, and A. H. Khan,Int. J. Appl. Rad. Isot. 35, 793 (1984).

    Article  CAS  Google Scholar 

  32. A. Gharib, H. Rahim, H. Pyrovan, N. J. Raoffi, and H. Taherpoor,J. Radioanal. Nucl. Chem. 89, 31 (1985).

    Article  CAS  Google Scholar 

  33. A. B. Hallak,J. Radioanal. Chem. 77, 83 (1983).

    Article  Google Scholar 

  34. B. R. Meyer, M. Peisach, and W. A. G. Kotze,Nucl. Instr. Meth. 193, 331 (1982).

    Article  CAS  Google Scholar 

  35. J. D. MacArthur, G. R. Palmer, K. Budd, W. E. Hekman, B. E. Nichol, and J. R. Casen,Nucl. Instrum. Meth. Phys. Res. B10/11, 653 (1985).

    Google Scholar 

  36. M. Ishikawa, K. Kitao, H. Imaseki, T. Ishii, and S. Uchida,J. Radioanal. Nucl. Chem. 82, 189 (1984).

    Article  CAS  Google Scholar 

  37. A. H. Legge, H. C. Kaufmann, and J. W. Winchester, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 507.

  38. G. S. Hall, and M. Naumann,J. Radioanal. Chem. Lett. 87, 317 (1984).

    Article  CAS  Google Scholar 

  39. C. P. Swann, M. R. Carriker, and J. W. Ewart, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 392.

  40. T. Raunemaa, A. Hautojarvi, K. Kaisla, M. Gerlander, R. Erkinjuntti, T. Tuomi, P. Hari, S. Kellomaki, and H. S. Katainen,Can. J. For. Res. 12, 384 (1982).

    CAS  Google Scholar 

  41. S. Matsumoto, T. Ito, A. Ito, K. Tsuchiya, R. Chiba, K. Kitao,Radiat. Environ. Biophys. 23, 287 (1984).

    Article  PubMed  CAS  Google Scholar 

  42. C. Ender, M. Q. Li, B. Martin, B. Povh, R. Nobiling, H. D. Reiss, and K. Traxel,Protoplasma 116, 201 (1983).

    Article  CAS  Google Scholar 

  43. H. A. Van Rinsvelt, R. Sater, R. W. Hurd, and J. M. Andres,Nucl. Instr. Meth. Phys. Res. B10/11, 660 (1985).

    Article  Google Scholar 

  44. R. W. Hurd, H. A. Van Rinsvelt, B. J. Wilder, B. Karas, W. Maenhut, and L. De Reu,Neurology 34, 1393 (1984).

    PubMed  CAS  Google Scholar 

  45. U. Lindh and O. Nilsson, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 641.

  46. C. Ender and R. Nobiling, ibid, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 621.

  47. L. D. McCormick,Biophys. J. 47, 381 (1985).

    PubMed  CAS  Google Scholar 

  48. R. D. Vis, Amsterdam, personal communication (1985).

  49. G. Chittleborough,Sci. Total Environ. 14, 53 (1980).

    Article  PubMed  CAS  Google Scholar 

  50. K. G. Malmqvist, Lund, Personal Communication, 1985.

  51. E. Clayton and K. K. Wooller,IEEE Trans. Nucl. Sci. NS-30, 1631 (1983).

    Google Scholar 

  52. E. Clayton, J. F. Chapman, and K. K. Wooler, ibid,NS-30, 1323 (1983).

    Google Scholar 

  53. E. Clayton and K. K. Wooller,Anal. Chem. 57, 1075 (1985).

    Article  PubMed  CAS  Google Scholar 

  54. K. Kemp and G. Danscher,Histochemistry 59, 167 (1979).

    Article  PubMed  CAS  Google Scholar 

  55. C. C. Perry, S. Mann, R. J. P. Williams, F. Watt, G. W. Grime, and J. Takacs,Proc. R. Soc. Lond. B222, 439 (1984).

    Article  Google Scholar 

  56. J. L. Campbell, S. Faiq, R. S. Gibson, S. B. Russell, and C. W. Schulte,Anal. Chem. 53, 1249 (1981).

    Article  PubMed  CAS  Google Scholar 

  57. H. K. Li, K. G. Malmqvist, L. E. Carlsson, and K. R. Akselsson, ref. (5) B. Martin, ed.,, p. 347; and H. K. Li and K. G. Malmqvist,Sci. Total Environ. 42, 213 (1985).

    Article  Google Scholar 

  58. G. S. Hall, N. Roach, U. Simmons, H. Cong, M. I. Li, and E. Cummings,J. Radioanal. Nucl. Chem. 82, 329 (1984).

    Article  CAS  Google Scholar 

  59. R. S. Gibson and I. Gibson,Sci. Total Environ. 39, 93 (1984).

    Article  PubMed  CAS  Google Scholar 

  60. M. F. Mahrok D. Crumpton, and P. E. Francois,Nucl. Instr. Meth. Phys. Res. B4, 120 (1984).

    Article  Google Scholar 

  61. J. A. Cookson and F. D. Piling,Phys. Med. Biol. 20, 1015 (1975).

    Article  PubMed  CAS  Google Scholar 

  62. J. P. W. Houtman, A. Bos, R. Vis, J. A. Cookson, and P. S. Tjioe,J. Radioanal. Chem. 70, 191 (1982).

    CAS  Google Scholar 

  63. K. M. Hambidge,Am. J. Clin. Nutr. 36, 943 (1982).

    PubMed  CAS  Google Scholar 

  64. J. W. Copius Peereboom and E. I. Hamilton, ed., Trace Elements, Human Health, and Hair Analysis,Sci. Total Environ. vol. 42, nos. 1–2, Elsevier, Amsterdam, 1985.

    Google Scholar 

  65. B. Moeller, L. E. Carlsson, G. I. Johansson, K. G. Malmqvist, L. Hammarstroem, and M. Berlen,Scand. J. Work Environ. Health 8, 267 (1982).

    CAS  Google Scholar 

  66. K. Haavikko, A. Anttila, A. Helle, and E. Vuori,Arch. environ. Health 39, 78 (1984).

    PubMed  CAS  Google Scholar 

  67. M. A. Chaudhri, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International conference).Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 643.

  68. M. A. Chaudhri and A. Crawford,Nucl. Instr. Meth. 181, 327 (1981).

    Article  CAS  Google Scholar 

  69. D. Brune, G. Brunell, and U. Lindh, ibid,,197, 209 (1982).

    Article  CAS  Google Scholar 

  70. S. K. Biswas, M. Abdullah, S. Akhter, S. A. Tarafdar, M. Khaliquzzaman, and A. H. Khan,J. Radioanal. Nucl. Chem. 82, 111 (1984).

    Article  CAS  Google Scholar 

  71. A. S. Paschoa, G. B. Baptista, G. M. Mauricio, C. V. Barros Leite, Y. B. Lerner, and P. F. Issler, ref. (5), B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference).Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 352.

  72. F. Sommer, Y. Barbier, M. Frachon, and M. Y. Chartoire,Nucl. Instrum. Meth. 205, 555 (1983).

    Article  CAS  Google Scholar 

  73. B. Forslind, G. M. Roomans, L. E. Carlsson, K. G. Malmqvist, and K. R. Akselsson,Scann. Electron Microsr. 1984, no. II, p. 755.

    Google Scholar 

  74. M. Goclowski, M. Jaskola, J. Ludziejewski, and R. Matusiewicz, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 163.

  75. W. Maenhaut, L. DeReu, and J. Vandenhaute, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 135.

  76. J. Versieck and R. Cornelis,Anal. chim. Acta 116, 217 (1980).

    Article  CAS  Google Scholar 

  77. R. Hallgren, K. Svensson, E. Johansson, and U. Lindh,J. Lab. Med. 104, 893 (1984); R. Hallgren, K. Svensson, E. Johansson, and U. Lindh,Arthritis and Rheumatism,28, 169 (1985); R. Hallgren, K. Svensson, E. Johansson, and U. Lindh,J. Rheumatology, in press; K. Svenson, R. Hallgren, E. Johansson, and U. Lindh,Am. J. Med. 12, 876 (1985).

    CAS  Google Scholar 

  78. J. Raisanen, M. Hyvonen-Dabek, and J. T. Dabek,Int. J. Appl. Rad. Isot. 32, 165 (1981).

    Article  CAS  Google Scholar 

  79. I. Borbely-Kiss, E. Koltay, S. Laszlo, G. Szabo, S. Godeny, and S. S. El-Nasr,J. Radioanal. Nucl. Chem. 83, 175 (1984).

    Article  CAS  Google Scholar 

  80. M. Hyvonen-Dabek, P. Nikkinen-Vilkki, and J. T. Dabek,Clin. Chem. 30, 529 (1984).

    PubMed  CAS  Google Scholar 

  81. P. Kiilholma, M. Gronroos, N. Nanto, and R. Paul,Acta Obstet. Gynecol. Scand. 63, 437 (1984).

    PubMed  CAS  Google Scholar 

  82. P. Kiilholma, M. Gronroos, R. Erkkola, P. Pakarinen, and V. Nanto,Gynecol. Obstet. Invest. 17, 194 (1984).

    PubMed  CAS  Google Scholar 

  83. P. Kiilholma, R. Erkkola, P. Pakarinen, and M. Gronroos, ibid,,18, 45 (1984).

    Article  PubMed  CAS  Google Scholar 

  84. M. Simonoff, Y. Llabador, C. Hamon, and G. N. Simonoff,Anal. Chem. 56, 454 (1984).

    Article  PubMed  CAS  Google Scholar 

  85. P. Pakarinen, J. Pallon, R. Akselsson, ref. (5), B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 168.

  86. L. Brazdes, M. Dumitru, T. Badica, C. Ciortea, A. Petrovici, and I. Popescu,Romanian J. Geront. Geriatr. 2, 117 (1981); ibid, L. Brazdes, M. Dumitru, T. Badica, C. Ciortea, A. Petrovici, and I. Popescu,Romanian J. Geront. Geriatr. 2, 117 (1981) p. 123; ibid, L. Brazdes, M. Dumitru, T. Badica, C. Ciortea, A. Petrovici, and I. Popescu,romanian J. Geront. Geriatr. 2, 117 (1981), p. 129.

    CAS  Google Scholar 

  87. J. Pallon, P. Pakarinen, and R. Akselsson, ref. (5), B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 373.

  88. M. Hyvonen-Dabek, J. Raisanen, and J. T. Dabek,J. Radioanal. Chem. 63, 163 (1981).

    Article  CAS  Google Scholar 

  89. M. Hyvonen-Dabek, ibid,, p. 367 (1981).

    Article  CAS  Google Scholar 

  90. U. Lindh,Int. J. Appl. Rad. Isot. 31, 737 (1980).

    Article  CAS  Google Scholar 

  91. U. Lindh, D. Brune, G. Nordberg, and P. O. Wester,Sci. Total Environ. 16, 109 (1980).

    Article  PubMed  CAS  Google Scholar 

  92. B. E. Taylor and S. A. Saied,Br. J. Urol. 54, 346 (1982).

    PubMed  CAS  Google Scholar 

  93. T. G. M. H. Dikhoff, J. A. van der Heide and J. G. McVie,Nucl. Instr. Meth. Phys. Res. B10/11, 639 (1985).

    Article  Google Scholar 

  94. B. Neinel, J. C. Bode, W. Koenig, and F. W. Richter,Biol. Neonate,36, 225 (1979).

    Article  Google Scholar 

  95. Z. A. Karcioglu, R. M. Sarper, H. A. Van Rinsvelt, J. A. Guffey, and R. W. Fink,Cancer 42, 1330 (1978).

    Article  PubMed  CAS  Google Scholar 

  96. E. B. Ilgren, D. J. T. Vaux, F. Watt, G. W. Grime, and J. Takacs,J. Neurosci. Meth. 12, 25 (1984).

    Article  CAS  Google Scholar 

  97. A. S. Paschoa, M. E. Wrenn, N. P. Singh, S. C. Miller, F. W. Bruenger, K. W. Jones, M. Cholewa, A. L. Hanson, and G. Saccomanno, preprint,Proc. Int. Conf. Occup. Rad. Safety in Mining, Toronto, 1984.

  98. U. Lindh,Nucl. Instr. Meth. 193, 343 (1982).

    Article  CAS  Google Scholar 

  99. N. F. Mangleson, M. W. Hill, K. K. Nielson, D. J. Eatough, J. J. Christensen, R. M. Izatt, and D. O. Richards,Anal. Chem. 51, 1187 (1979).

    Article  Google Scholar 

  100. H. Koyama-Ito, E. Wada, T. Tsumita, M. Horiuchi, and S. Iwata, ref. (5) B. Martin, ed., Particle-induced X-ray emission and its analytical applications (Proceedings of the Third International Conference),Nucl. Instr. Meth. Phys. Res. vol. B3 (1984), p. 625.

  101. S. Bauman, J. Nelson, and J. Winchester (eds.), Particle-induced X-ray emission and its analytical applications (Proceedings of the Fourth International Conference),Nucl. Instr. Meth. Phys. Res. (in press).

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Williams, E.T. Application of particle-induced X-ray emission to research in biology and medicine. Biol Trace Elem Res 12, 19–31 (1987). https://doi.org/10.1007/BF02796663

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