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Effects of excess selenomethionine on selenium status indicators in pregnant long-tailed macaques (Macaca fascicularis)

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Abstract

Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold,r=0.958), plasma selenium (22-fold,r=0.885), erythrocyte selenium (24-fold,r=0.920), and fecal selenium (18-fold,r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased 154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8 μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials.

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Author information

Author notes

  1. Kimberly A. Craig

    Present address: Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA

  2. Stanley T. Omaye

    Present address: Department of Nutrition, University of Nevada, 89557, Reno, NV

  3. Douglas N. Cox

    Present address: ENVIRON Corporation, 5820 Shellmound St., Suite 700, 94608, Emeryville, CA

Authors and Affiliations

  1. Western Human Nutrition Research Center, USDA-ARS, P.O. Box 29997, 94129, Presidio of San Francisco, CA

    Wayne Chris Hawkes

  2. Department of Health Services, State of California, 2151 Berkeley Way, 94704-1011, Berkeley, CA

    Calvin C. Willhite & Wai Nang Choy

  3. Western Human Nutrition Research Center, USDA-ARS, P.O. Box 29997, 94129, Presidio of San Francisco, CA

    Kimberly A. Craig

  4. Letterman Army Institute of Research, 94129, Presidio of San Francisco, CA

    Stanley T. Omaye

  5. California Public Health Foundation, 2001 Addison Street, 94704, Berkeley, CA

    Douglas N. Cox

  6. California Primate Research Center, University of California, 95616, Davis, CA

    Andrew G. Hendrickx

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  1. Wayne Chris Hawkes
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Hawkes, W.C., Willhite, C.C., Craig, K.A. et al. Effects of excess selenomethionine on selenium status indicators in pregnant long-tailed macaques (Macaca fascicularis). Biol Trace Elem Res 35, 281–297 (1992). https://doi.org/10.1007/BF02783772

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  • DOI: https://doi.org/10.1007/BF02783772

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