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Arachidonic acid metabolites in carbon tetrachloride-induced liver injury

  • Liver and Pancreas
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Summary

The changes in the levels of leukotrienes (LTs) and prostaglandins (PGs) in the liver tissue of rats with carbon tetrachloride (CCl4-induced liver injury were studied. As a result, after the administration of CCI4, the levels of LTs increased at an early stage while the levels of PGs increased at a later stage. This suggests that LTs may have an adverse effect on liver injury induced by CC14, and that PGs may not have a direct effect on liver injury. In addition, serum GOT and GPT levels improved with the administration of AA-861, a 5-lipoxygenase inhibitor, while these levels did not change with the administration of indomethacin, a cyclooxygenase inhibitor. These results suggest that arachidonic acid metabolites may play an important role in the induction of liver cell injury.

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Kawada, N., Mizoguchi, Y., Kobayashi, K. et al. Arachidonic acid metabolites in carbon tetrachloride-induced liver injury. Gastroenterol Jpn 25, 363–368 (1990). https://doi.org/10.1007/BF02779452

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  • DOI: https://doi.org/10.1007/BF02779452

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