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Anti-Albumin antibodies in sera of patients with liver disease

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Summary

We used passive haemagglutination assay to examine sera from 77 patients with various liver diseases for the presence of antibodies to human serum albumin (HSA), bovine serum albumin (BSA) and ovalbumin (OA). The antibody titre to BSA was higher than that to OA or HSA. Of the examined diseases, in chronic active hepatitis and liver cirrhosis, the titre and incidence of anti-BSA antibody were highest. There was a positive correlation between anti-BSA antibody and serum γ-globulin level. Sephadex G-200 column chromatography and immunoelectrophoresis revealed that the anti-BSA antibody belonged to the IgM class.

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Authors and Affiliations

  1. Second Department of Internal Medicine, Tottori University School of Medicine, 683, Yonago, Japan

    Noriaki Tamura M.D., Takeaki Suou M.D. & Chisato Hirayama M.D.

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  1. Noriaki Tamura M.D.
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  2. Takeaki Suou M.D.
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  3. Chisato Hirayama M.D.
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Tamura, N., Suou, T. & Hirayama, C. Anti-Albumin antibodies in sera of patients with liver disease. Gastroenterol Jpn 17, 469–475 (1982). https://doi.org/10.1007/BF02774725

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  • DOI: https://doi.org/10.1007/BF02774725

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