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Potentiation of PG effects on the intraocular muscles of the cat by inhibition of PG synthesis

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Summary

Various PG synthesis inhibitors potentiate the effects of PGE1, E2 and F2α on isolated sphincter, dilator and ciliary muscles of the cat when added to the bath or injected intravenously. Potentiation depends on dose and type of PG synthetase inhibitor. A hypothesis for the potentiation is discussed.

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Abbreviations

PG:

prostaglandin

Es:

eserine

Ach:

acetylcholine

References

  • van Alphen, G.W.H.M. & M.A. Angel. Activity of prostaglandin E, F, A and B on sphincter, dilator and ciliary muscle preparations of the cat eye.Prostaglandins 9:157–166 (1975).

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  • van Alphen, G.W.H.M., S.L. Robinette & F.J. Macri. The adrenergic receptors of the intraocular muscles of the cat.Internat. J. Neuropharm. 2:259–272 (1964).

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  • van Alphen, G.W.H.M., P.B. Wilhelm & P.W. Eisenfeld. The effect of PG’s on the isolated internal muscles of the mammalian eye, man included.Doc. Ophthal. 42:000–000 (1977).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The University of Michigan, Ann Arbor, Michigan, USA

    Peter B. Wilhelm & G. W. H. M. Van Alphen

  2. Netherlands Ophthalmic Research Institute, Wilhelmina Gasthuis, Amsterdam, The Netherlands

    Peter B. Wilhelm & G. W. H. M. Van Alphen

Authors
  1. Peter B. Wilhelm
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  2. G. W. H. M. Van Alphen
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Wilhelm, P.B., Van Alphen, G.W.H.M. Potentiation of PG effects on the intraocular muscles of the cat by inhibition of PG synthesis. Doc Ophthalmol 42, 417–423 (1977). https://doi.org/10.1007/BF02742256

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  • DOI: https://doi.org/10.1007/BF02742256

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