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Reduction in HLA-DR antigen density on alveolar macrophages of smokers

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Abstract

The expression of HLA class II genes is essential to the antigen-presenting function of monocytes and macrophages. With a new cytofluorometric method of single-cell analysis we investigated the density of HLA-DR antigen expression on alveolar macrophages (AM) of smokers. Although all AM of nonsmokers (100±1%) expressed HLA-DR antigens, only 79 ± 12% of AM from smokers showed positive findings (p<0.001). Furthermore, the antigen density of those cells expressing this antigen was significantly reduced in smokers (p<0.001). The defective expression of class II genes on AM of smokers might contribute to the impaired antigen-presenting function found by some previous investigators.

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Authors and Affiliations

  1. Department of Internal Medicine, Philipps-University Medical Center, Baldingerstraße, D-3550, Marburg, Federal Republic of Germany

    Wulf Pankow, Reiner Schröder & Peter von Wichert

  2. Department of Pathology, Hospital of the Philipps University, Marburg, Germany

    Kurt Neumann & Josef Rüschoff

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  1. Wulf Pankow
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  2. Kurt Neumann
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  3. Josef Rüschoff
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  4. Reiner Schröder
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  5. Peter von Wichert
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Pankow, W., Neumann, K., Rüschoff, J. et al. Reduction in HLA-DR antigen density on alveolar macrophages of smokers. Lung 169, 255–262 (1991). https://doi.org/10.1007/BF02714161

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