Skip to main content
SpringerLink
Log in

Quantification and imaging of myocardial sodium and creatine kinase metabolites

  • Published:
Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Jennings RB, Reimer KA. Lethal myocardial ischemic injury. Am J Pathol 1981;102:241–55.

    PubMed  CAS  Google Scholar 

  2. Jennings RB, Sommers HM, Kaltenbach JP, West JJ. Electrolyte alterations in acute myocardial ischemic injury. Circ Res 1964;14:260–9.

    Article  PubMed  CAS  Google Scholar 

  3. Bottomley PA. Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy. Science 1985;229:769–72.

    Article  PubMed  CAS  Google Scholar 

  4. Weiss RG, Bottomley PA, Hardy CJ, Geisteath, G.. Regional myocardial metabolism of high-energy phosphates during isometric exercise in patients with coronary area disease. New Engl J Med 1990;323:1593–600.

    Article  PubMed  CAS  Google Scholar 

  5. Yabe T, Mitsunami K, Okada M, Monkara S, Inubushi T, Kinoshita M. Detection of myocardial ischemic by 31P magnetic resonance spectroscopy during handgrip exercise. Circulation 1994;89:1709–16.

    Article  PubMed  CAS  Google Scholar 

  6. Neubauer S, Krahe T, Schindler R, Horn M, Hillenbrand H, Entzeroth C, Mader H, Kromer EP, Riegger GAJ, Lackner K, Ertl G. 31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Circulation 1992;86:1810–8.

    Article  PubMed  CAS  Google Scholar 

  7. Bottomley PA, Atalar E, Weiss RG. Human cardiac high-energy phosphate metabolite concentrations by ID-resolved NMR spectroscopy. Magn Reson Med 1995;35:664–70.

    Article  Google Scholar 

  8. Bottomley PA, Weiss RG. Noninvasive MRS detection of localized creatine depletion in non-viable, infarcted myocardium. The Lancet 1998;351:714–8.

    Article  CAS  Google Scholar 

  9. Bottomley PA, Weiss RG. Reductions in creatine kinase metabolite concentrations in infarcted myocardium by noninvasive MRS. Proc ISMRM 1997;1:480.

    Google Scholar 

  10. Yabe T, Mitsunami K, Inubushi T, Kinoshita M. Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopy. Circulation 1995;92:15–23.

    Article  PubMed  CAS  Google Scholar 

  11. Bottomley PA, Hardy CJ. Mapping creatine kinase reaction rates in human brain and heart with 4 Tesla saturation transfer 31P NMR. J Magn Reson 1992;99:443–8.

    CAS  Google Scholar 

  12. Ouwerkerk R, Lee R, Weiss RG, Bottomley P. A new FAST method for in vivo measurement of chemical exchange rates. Proc Int Soc Magn Reson Med 2000;1:421.

    Google Scholar 

  13. Ra JB, Hilal SK, Oh CH, Mun IK. In vivo magnetic resonance imaging of sodium in the human body. Magn Reson Med 1988;7:11–22.

    Article  PubMed  CAS  Google Scholar 

  14. Kim RJ, Lima JOAC, Chen EL, Reeder SB, Klocke FJ, Zerhouni EA, Judd RM. Fast 23Na magnetic resonance imaging of acute reperfused myocardial infarction. Potential to assess myocardial viability. Circulation 1997;95:1877–85.

    Article  PubMed  CAS  Google Scholar 

  15. Constantinides CD, Weiss RG, Lee R, Bolar D, Bottomley PA. Restoration of low resolution metabolic images with a priori anatomic information: 23Na MRI in myocardial infarction. Magn Reson Imag 2000;18:461–71.

    Article  CAS  Google Scholar 

  16. Lee RF, Giaquinto R, Constantinides CD, Souza S, Weiss RG, Bottomley PA. A broadband phased-array system for direct phosphorus and sodium metabolic MRI on a clinical scanner. Magn Reson Med 2000;43:269–77.

    Article  PubMed  CAS  Google Scholar 

  17. Constantinides CD, Gillen JS, Boada FE, Pomper MG, Bottomley PA. Human skeletal muscle: 23Na MR imaging and quantification-potential applications in exercise and disease. Radiology 2000;216:559–68.

    PubMed  CAS  Google Scholar 

  18. Constantinides CD, Kraitchman D, O’Brien K, Boada F, Gillen J, Bottomley PA. Noninvasive quantification of total sodium concentrations in myocardial infarction using 23Na MRI. Proc Int Soc Magn Reson Med 2000;1:130.

    Google Scholar 

  19. Ouwerkerk R, Lee RF, Bottomley PA. Dynamic changes in sodium levels in human exercising muscle measured with 23Na MRI. Proc Intl Soc Mag Reson Med 1999;3:1530.

    Google Scholar 

  20. Bottomley PA, Hardy CJ. Proton Overhauser enhancements in human cardiac phosphorus NMR spectroscopy at 1.5-T. Magn Reson Med 1992;24:384–90.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of MR Research, Department of Radiology, Johns Hopkins University, 601 N Caroline Street, 21287-0843, Baltimore, MD, USA

    Paul A. Bottomley, Ray F. Lee & Ronald Ouwerkerk

  2. Department of Biomedical Engineering, Johns Hopkins University, 720 Ruthland Street, 21205, Baltimore, MD, USA

    Chris D. Constantinides

  3. Division of Cardiology, Johns Hopkins University, 600 N Wolfe Street, 21287, Baltimore, MD, USA

    Robert G. Weiss

Authors
  1. Paul A. Bottomley
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ray F. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chris D. Constantinides
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ronald Ouwerkerk
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert G. Weiss
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Paul A. Bottomley.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bottomley, P.A., Lee, R.F., Constantinides, C.D. et al. Quantification and imaging of myocardial sodium and creatine kinase metabolites. MAGMA 11, 39–41 (2000). https://doi.org/10.1007/BF02678489

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02678489

Keywords

Search

Navigation