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Studies of cyclic AMP action using mutant tissue culture cells

  • Symposia Proceeding
  • Mechanisms of Cellular Control
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Summary

S49 mouse lymphoma cell mutants, each with a specific defect in its ability to generate or respond to cyclic AMP, have been isolated. Analysis of the properties of these cells has begun to provide information on complex and significant biologic problems related to the cyclic AMP system.

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Authors and Affiliations

  1. Division of Clinical Pharmacology, Department of Medicine, University of California, San Francisco, 94143, San Francisco, California

    Gary Johnson

  2. Department of Microbiology, University of California, San Francisco, 94143, San Francisco, California

    Philip Coffino

  3. Cardiovascular Research Institute, University of California, San Francisco, 94143, San Francisco, California

    Henry R. Bourne, Paul A. Insel, Kenneth L. Melmon & Josefina Vigne

  4. Deparment of Pharmacology, University of California, San Francisco, 94143, San Francisco, California

    Henry R. Bourne, Paul A. Insel & Kenneth L. Melmon

Authors
  1. Philip Coffino
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  2. Henry R. Bourne
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  3. Paul A. Insel
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  4. Kenneth L. Melmon
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  5. Gary Johnson
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  6. Josefina Vigne
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Additional information

The work was supported in part by National Science Foundation Grant BMS 75-06764 and National Institutes of Health Grants GM 16496 and GM 00001. P.C. is the recipient of National Institutes of Health Research Career Development Award GM 00308. P. A. I. is an Established Investigator of the American Heart Association.

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Coffino, P., Bourne, H.R., Insel, P.A. et al. Studies of cyclic AMP action using mutant tissue culture cells. In Vitro 14, 140–145 (1978). https://doi.org/10.1007/BF02618180

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