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Transferable sodium arsenate resistance in enterobacteriaceae

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Abstract

The sodium arsenate and antibiotic resistance of a total of 750 strains of Enterobacteriaceae andPseudomonas aeruginosa isolated from hospital patients was determined. Resistance to sodium arsenate (minimal inhibitory concentration ≥25 mg/ml) was found in 61.4% of the isolates and was present both in antibiotic-susceptible and antibiotic-resistant strains. Ten enterobacterial isolates (3 sodium arsenate-resistant, antibiotic-susceptible strains and 7 sodium arsenate-resistant, antibiotic-resistant strains) could transfer sodium arsenate resistance to susceptible isolates and toEscherichia coli K-12 by conjugation. From sodium arsenate-and antibioticresistant strains, sodium arsenate and antibiotic resistances were transferred en bloc. Sodium arsenate resistance of antibiotic-susceptible strains was not self-transmissible, and transfer occurred only after R-plasmid mobilization.

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Authors and Affiliations

  1. Department of Bacteriology and Virology, Faculty of Medicine, 28, place H. Dunant, F-63001, Clermont-Ferrand Cedex, France

    B. H. Joly, R. A. Cluzel, S. M. Petit & M. E. Chanal

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  1. B. H. Joly
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  2. R. A. Cluzel
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  3. S. M. Petit
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  4. M. E. Chanal
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Joly, B.H., Cluzel, R.A., Petit, S.M. et al. Transferable sodium arsenate resistance in enterobacteriaceae. Current Microbiology 2, 151–155 (1979). https://doi.org/10.1007/BF02605873

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