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Determination of nanogram quantities of gold in biological tissues by nondestructive neutron activation analysis

  • Physical Methods Section
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Abstract

We describe a method for gold analysis in kidney and liver. The technique is simpler than other methods in that it does not require ashing or acid digestion of the sample. The tissue is dried, placed into a polyethylene vial and diluted with a 2 ml sodium chloride solution. Gold concentration is determined by neutron activation analysis. Samples are irradiated for two hours at a thermal neutron flux of 1012n·cm−2·s−1 and are then allowed to decay for 3–4 days before counting. The detection limit (20 ng Au/ml) and precision (±6.1%) permits the accurate analysis of gold in these tissues. This technique could aid in a re-examination of gold metabolism.

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Authors and Affiliations

  1. Department of Medicine, Michigan State University, 48824, East Lansing, Michigan, (USA)

    S. M. Sprague

  2. Engineering Research, Michigan State University, 48824, East Lansing, Michigan, (USA)

    J. T. Carrick

  3. Chemical Engineering, Michigan State University, 48824, East Lansing, Michigan, (USA)

    B. W. Wilkinson

  4. Medicine 8 Surgery, Michigan State University, 48824, East Lansing, Michigan, (USA)

    G. H. Mayor

Authors
  1. S. M. Sprague
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  2. J. T. Carrick
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  3. B. W. Wilkinson
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  4. G. H. Mayor
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Sprague, S.M., Carrick, J.T., Wilkinson, B.W. et al. Determination of nanogram quantities of gold in biological tissues by nondestructive neutron activation analysis. J. Radioanal. Chem. 52, 421–426 (1979). https://doi.org/10.1007/BF02521293

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  • DOI: https://doi.org/10.1007/BF02521293

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