Abstract
Neurophysiological manifestations of formation of the dependence on ethanol under stress conditions were studied in rats and their first generation offspring. In chronic experiments on 32 male rats, emotional stress was modeled (induction by nociceptive electrocutaneous stimulation), and an increased addiction to ethanol was formed. In these animals and in the first generation of their offspring (obtained from the above males and intact females), we studied emotional/motivational behavior, recorded the mass electrical activity from different brain structures, and measured the arterial pressure. In stressed rats, which acquired attraction to ethanol, negative emotional responses became transformed into positive, and behavioral and electrographic manifestations of the seizure activity developed. In the first generation offspring, the pattern of central rearrangements in the mechanisms of emotional/motivational behavior was to a great extent similar to that in parent rats.
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Toumanova, V.V. Effects of stress and alcohol consumption on emotional/motivational behavior of rats and their first generation offspring. Neurophysiology 31, 32–34 (1999). https://doi.org/10.1007/BF02515008
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DOI: https://doi.org/10.1007/BF02515008