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Dependence of tetanic hyperpolarization on pump conductance in the cyanide-treatedXenopus node

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Abstract

Prolonged exposure to cyanide leads to a delayed but reversible disappearance of tetanic hyperpolarization in theXenopus node (G. M. Schoepfle,Am. J. Physiol. 231, 1033–1038, 1976). This effect is attributed to a pronounced decline in the absolute values of the ATP and ADP concentrations, such that the ATP-driven ion translocation is no longer possible, regardless of the existing values for (Na)i, (K)i and the (ATP)/(ADP) ratio. Mathematically, this would imply a vanishing of a constant pump conductance gp in the exression for electrogenic pump current densitityJ p, whereJ p=g p (V m −E p) in whichV m is membrane potential andE p is an ATP-and sodium-dependent e.m.f.

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Authors and Affiliations

  1. Department of Psychiatry, Neurosciences Program, University of Alabama in Birmingham, 35294, Birmingham, AL, USA

    Gordon M. Schoepfle

  2. Department of Physics, University of Mississippi, 38655, Oxford, MS, USA

    John T. Tarvin

  3. Department of Neurology, University of Alabama in Birmingham, 35294, Birmingham, AL, USA

    Richard M. Martin

Authors
  1. Gordon M. Schoepfle
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  2. John T. Tarvin
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  3. Richard M. Martin
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Supported by NIH grant NS08802.

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Schoepfle, G.M., Tarvin, J.T. & Martin, R.M. Dependence of tetanic hyperpolarization on pump conductance in the cyanide-treatedXenopus node. Bltn Mathcal Biology 47, 749–755 (1985). https://doi.org/10.1007/BF02469301

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  • DOI: https://doi.org/10.1007/BF02469301

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