Abstract
Experiments were carried out on rats to study the dynamics of recovery of a conditioned reflex to time after electrolytic lesioning of the dorsal hippocampus and the effects of hippocampectomy on the development of this response. Lesioning of the hippocampus deranged the restoration of a conditioned reflex to time which had been fixed before surgery. In conditions of limited hippocampal damage, the conditioned reflex to time recovered earlier than in sham-operated animals. Animals with more significant damage showed delays in the recovery of the response to time. After hippocampectomy without initial training, the conditioned reflex to time could not be developed regardless of the extent of damage to the hippocampus. This process was also not affected by doses of phenamine of 0.05 mg/kg.
Similar content being viewed by others
References
O. S. Adrianov, “Cerebral interactions of cognitive and emotional activity,” Zh. Vyssh. Nerv. Deyat.,45, No. 3, 441 (1995).
É. B. Arushanyan, “The contribution of the neostriatum to the rhythmic organization of brain activity and the adaptive behavior of animals,” Usp. Fiziol. Nauk.,23, No. 1, 58 (1992).
É. B. Arushanyan, V. A. Baturin, and A. V. Popov, “The suprachiasmatic nucleus of the hippocampus as a regulator of the circadian system in mammals,” Usp. Fiziol. Nauk.,19, No. 2, 67 (1988).
É. B. Arushanyan, V. A. Baturin, A. V. Popov, et al., “The effects of lesioning the suprachiasmatic nuclei of the hippocampus on swimming dynamics and haloperidol catalepsy in rats,” Fiziol. Zh. SSSR,74, No. 9, 1221 (1988).
Ya. Buresh, O. Bureshova, and D. P. Houston, Methods and Basic Experiments for the Study of the Brain and Behavior [in Russian], Vysshaya Shkola, Moscow (1991).
O. S. Vinogradova, E. S. Brazhnik, V. F. Kichigina, and V. S. Stafekhina, “Modulation by cholinergic substances of hippocampal neuron responses to sensory stimuli,” Zh. Vyssh. Nerv. Deyat.,45, No. 1, 118 (1995).
T. A. Mering and E. I. Mukhin, “The effects of hippocampal lesions on conditioned reflexes to time,” Zh. Vyssh. Nerv. Deyat.,21, No. 6, 1147 (1971).
T. A. Mering, A. A. Ungiadze, and I. V. Viktorov, “The state of conditioned reflex activity and the EEG in rats after cholic acid lesioning of the hippocampus,” in: Collected Works, Science Research Institute of the Brain, No. 17, USSS Academy of Medical Sciences [in Russian] (1990), p. 140.
B. S. Bunney, Y. R. Walter, M. Kuhar, et al., “D- and L-amphetamine steroisomers: Comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons,” Psychopharmacol. Commun.,1, 177 (1975).
S. D. Glick and R. C. Marsanico, “Time-dependent changes in amphetamine self-administration following frontal cortex ablation in rats,” J. Comp. Physiol. Psychol.,88, 355 (1975).
S. D. Glick, R. C. Marsanico, and S. Greenstein, “Differential recovery of function following caudato-hippocampal and striatal lesions in mice,” J. Comp Physiol. Psychol.,86, 787 (1974).
J. F. Konig and R. A. Lippel, The Rat Brain. A Stereotaxic Atlas, R. E. Krieger Publishers, New York (1963).
V. G. Laties and B. Weiss, “Influence of drugs on behavior controlled by internal and external stimuli,” J. Pharmacol. Exp. Therapeutics,152, 388 (1966).
T. Otto, H. Eichenbaum, S. I. Wiener, and C. B. Wible, “Learning-related patterns of CAI spike trains parallel stimulation parameters optimal for inducing hippocampal long-term potentiation,” Hippocampus,1, 181 (1991).
S. N. Pradhan and S. N. Dutta, “Comparative effects of nicotine and amphetamine on timing behavior in rats,” Neuropharmacol.,9, 9 (1970).
W. A. Suzuki, S. Zola-Morgan, L. R. Squire, and D. G. Amaral, “Lesions of perirhinal and parahippocampal cortices in the monkey produce long-lasting memory impairment in the visual and tactile modalities,” J. Neurosci.,13, 2430 (1993).
Additional information
Department of Physiology, State University, Stavropol’. Department of Pharmacology, Medical Academy, Stavropol’. Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 47, No. 3, pp. 480–486, May–June, 1997.
Rights and permissions
About this article
Cite this article
Vodolazhskaya, M.G. Effects of hippocampectomy on the development and recovery of a conditioned reflex to time in rats. Neurosci Behav Physiol 28, 527–532 (1998). https://doi.org/10.1007/BF02463013
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02463013