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Pattern triplications following genetic ablation on the wing ofDrosophila

Effect of eliminating thepolyhomeotic gene

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Summary

The effects ofpolyhomeotic (ph) mutants in imaginal cells have been studied in a clonal analysis. Clones of cells, homozygous forph, sort-out after a few divisions, probably as a consequence of modified cell affinities. The dorso-ventral margin of the wing has special characteristics that retard this phenomenon. The formation and exclusion of a clone of 8–16 cells affect the polarity of the wild-type neighbour cells and can provoke pattern triplications. The results suggest that a defect in intercellular communication prevents the wild-type cells from maintaining coordinated positional information. The cells react by regenerative growth, and reorganize into a new pattern. The pleiotropic phenotypes ofph mutants are explained according to a common hypothesis aboutph + function.

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Authors and Affiliations

  1. Centre de Génétique Moléculaire du C.N.R.S., F-91198, Gif-sur-Yvette Cedex, France

    Pedro Santamaria, Janet Deatrick & Neel B. Randsholt

  2. Laboratoire propre du C.N.R.S., associe à l'Université Pierre et Marie Curie, Paris VI, France

    Pedro Santamaria, Janet Deatrick & Neel B. Randsholt

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  1. Pedro Santamaria
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  2. Janet Deatrick
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  3. Neel B. Randsholt
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Santamaria, P., Deatrick, J. & Randsholt, N.B. Pattern triplications following genetic ablation on the wing ofDrosophila . Roux's Arch Dev Biol 198, 65–77 (1989). https://doi.org/10.1007/BF02447741

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  • DOI: https://doi.org/10.1007/BF02447741

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