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Effect of superlow doses of phenazepam on the EEG and behavior of rats in different models of anxiety

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Phenazepam administered in superlow doses exerts an anxiolytic effect in albino male rats under conditions of plus-maze and conflict test and induces typical inhibition of θ-activity in the EEG. Contrary to the effect of usual doses, other frequency intervals remain practically unchanged. Phenazepam in superlow doses acts as an anxioselective tranquilizer.

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Authors and Affiliations

  1. Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    T. A. Voronina, G. M. Molodavkin, L. I. Chernyavskaya, S. B. Seredenin & E. B. Burlakova

  2. N. E. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow

    T. A. Voronina, G. M. Molodavkin, L. I. Chernyavskaya, S. B. Seredenin & E. B. Burlakova

Authors
  1. T. A. Voronina
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  2. G. M. Molodavkin
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  3. L. I. Chernyavskaya
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  4. S. B. Seredenin
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  5. E. B. Burlakova
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 308–310, September, 1997

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Voronina, T.A., Molodavkin, G.M., Chernyavskaya, L.I. et al. Effect of superlow doses of phenazepam on the EEG and behavior of rats in different models of anxiety. Bull Exp Biol Med 124, 894–896 (1997). https://doi.org/10.1007/BF02446995

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  • DOI: https://doi.org/10.1007/BF02446995

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