Abstract
EEGs recorded from the cerebral cortex of rats with high and low resistance to hypoxia during “elevation” in a pressure chamber differ in the dynamics of the EEG power spectra. EEGs of highly resistant rats show phasic changes in biopotentials correlating with the severity of hypoxia: primary increase in the absolute power of all frequency ranges is followed by normalization and a secondary increase with predominance of the slow-wave component, inhibition of the β2 range and the emergence of interhemispheric differences, and terminal inhibition of the power of all frequency ranges. In rats with low resistance to hypoxia, phases of relative normalization of EEG spectra and their depression during terminal period are not observed, all changes being represented by a continuous increase in the power of the α and δ ranges with progressive inhibition of the β2 range and then of the β1 range. Interhemispheric asymmetry is significant throughout the period of power increase. A high amplitude burst activity is recorded in rats of both types starting from an altitude of 8000 or 9000 m. The pattern of EEG changes in rats exposed to hypoxia of growing severity consistently reproduces those observed in patients with ischemic stroke.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 9, pp. 262–267, September, 1996
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Malyshev, A.Y., Luk'yanova, L.D. & Krapivin, S.V. Effect of hypoxia of increasing severity on the dynamics of cerebral cortex EEGs in rats with different resistance to acute oxygen deficiency. Bull Exp Biol Med 122, 879–884 (1996). https://doi.org/10.1007/BF02446569
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DOI: https://doi.org/10.1007/BF02446569