Abstract
The effects of endogenous dipeptide cycloprolyl-glycine on learning and memory in the model of postconvulsive retrograde amnesia of passive avoidance response in rats depended on the administration schedule. The dipeptide prevented retrograde amnesia, when injected prior to learning, had no effect after postlearning administration, and aggravated amnesia, when injected immediately before retrieval. These data suggest that cycloprolyl-glycine is similar to the standard nootropic piracetam by its mnemotropic activity.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol.128, No. 10, pp. 411–413, October, 1999
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Gudasheva, T.A., Ostrovskaya, R.U., Trofimov, S.S. et al. New endogenous dipeptide cycloprolyl-glycine is similar to piracetam by its mnemotropic selectivity. Bull Exp Biol Med 128, 1012–1014 (1999). https://doi.org/10.1007/BF02433192
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DOI: https://doi.org/10.1007/BF02433192