Skip to main content
SpringerLink
Log in

Study on analysis of153Sm-EDTMP stability in vitro and vivo by HPLC

  • Applications of Radioanalytical Methods to Biological and Clinical Systems
  • Published:
Journal of Radioanalytical and Nuclear Chemistry Aims and scope Submit manuscript

Abstract

The behavior of153Sm-EDTMP in vitro and vivo is analyzed by the size exclusion HPLC. The experimental results show that EDTMP amounts have an obvious effect on the stability in vitro and uptake of153Sm-EDTMP in the liver. HPLC analysis of urine sample indicates that153Sm-EDTMP es excreted in the original form. The behavior in vivo of153Sm-EDTMP containing 4 μg is similar to that of153Sm-EDTMP containing 50 μg EDTMP at 1 h post-injection.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. S. Amolak, A. Richard, M. Holmes, J. Nucl. Med., 30 (1989) 1814.

    Google Scholar 

  2. W. F. Goeckler, B. Edwards, W. A. Volkert et al., J. Nucl. Med., 28 (1987) 475.

    Google Scholar 

  3. W. F. Goeckler, D. E. Troutner, B. Edwards et al., Nucl. Med. Biol., 13 (1986) 479.

    Google Scholar 

  4. M. S. Soloway, S. W. Hardeman, D. Hickey et al., Cancer, 61 (1988) 195.

    CAS  Google Scholar 

  5. X. H. Jin, H. S. Bai, J. Du et al., The 6th Asia & Ocean Congress of Nuclear Medicine and Biology in conjunction with The 36th Annual Meeting of the Japanese Society of Nuclear Medicine, Sep. 30–Oct 4, 1996, Kyoto, Japan.

  6. D. M. Chen, X. H. Jin, J. Du et al., The 10th Pacific Basin Nuclear Conference, Kobe, Japan, Oct., 1996, p. 20.

Download references

Author information

Authors and Affiliations

  1. Department of Isotope, China Atomic Energy Institute, P. O. Box 275(58), 102413, Beijing, P. R. China

    H. Sh. Bai, H. X. Jin, H. Q. Fan, F. Wang & D. M. Chen

  2. MAP Medical Technologies Oy, Elementtitie 27, FIN-41160, Tikkakosi, Finland

    J. Du

  3. 1205 University Ave., Apt 316, 65201, Columbia, MO, USA

    Zh. Cheng

Authors
  1. H. Sh. Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. X. Jin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. Q. Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. D. M. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zh. Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bai, H.S., Jin, H.X., Fan, H.Q. et al. Study on analysis of153Sm-EDTMP stability in vitro and vivo by HPLC. J Radioanal Nucl Chem 236, 87–95 (1998). https://doi.org/10.1007/BF02386323

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02386323

Keywords

Search

Navigation