Abstract
In the ovarian cycle of common marmosets, serum progesterone began to increase at two to three days after estradiol-17β or LH surge, attained a peak of 25–70 ng/ml and then declined to a level of under 2 ng/ml before the ensuing rise in estradiol-17β and LH. Serum estradiol-17β increased to 700–5,500 pg/ml during the luteal phase, synchronizing with progesterone. It is suggested that the corpus luteum secreted estradiol-17β as well as progesterone. The cycle length as determined from the interval between successive LH surges was approximately 28 days. During the luteal phase, the levels of progesterone and estradiol-17β were higher than in Old World monkeys and women, but marmosets were not accompanied by any clinical symptoms due to excessive progesterone and estradiol-17β. This suggests that such unresponsiveness to progesterone and estradiol-17β in marmosets reflects the small amount of estradiol-17β receptor and presumably also the lower function of the post receptor system.
Recovery of the post-partum ovarian cycle in two marmosets differed from that observed in Old World monkeys and women. The first LH surge was found on the ninth and tenth day after parturition and the first ovulation led to the next pregnancy. This suggests that the suckling stimulus of newborns in the common marmoset does not cause any delay in recovery of the ovarian cycle. In three cases of abortion, the recovery of the ovarian cycle was almost the same as that in the case of normal parturition: the first LH surge appeared on the 10th, 14th, and 34th day after abortion.
Similar content being viewed by others
References
Baird, D. J., T. G. Baker, K. P. McNatty, &P. Neal, 1975. Relationship between the secretion of the corpus luteum and the length of the follicular phase of the ovarian cycle.J. Reprod. Fertil., 45: 611–619.
Butler, W. R., L. C. Krey, K. H. Lu, W. D. Peckham, &E. Knobil, 1975. Surgical disconnection of the medical basal hypothalamus and pituitary function in the rhesus monkey. IV. Prolactin secretion.Endocrinology, 96: 1099–1105.
Chambers, P. L. &J. P. Hearn, 1979. Peripheral plasma levels of progesterone, oestradiol-17β, oestrone, testosterone, androstenedione and chorionic gonadotrophin during pregnancy in the marmoset monkey,Callithrix jacchus.J. Reprod. Fertil., 56: 23–32.
Deinhardt, F., A. W. Holmes, R. B. Capps, &H. Popper, 1967. Studies on the transmission of human viral hepatitis to marmoset monkey. I. Transmission of disease, serial passages, and description of liver lesions.J. Exp. Med., 125: 673–688.
Hampton, J. K. Jr., B. M. Levy, &P. M. Sweet, 1969. Chorionic gonadotrophin excretion during pregnancy in the marmoset,Callithrix jacchus.Endocrinology, 85: 171–174.
Harding, R. D., M. J. Holme, S. F. Lunn, C. Henderson, &R. J. Aitken, 1982. Plasma progesterone levels throughout the ovarian cycle of the common marmoset (Callithrix jacchus).J. Med. Primatol., 11: 43–51.
Harlow, C. R., S. Gems, J. K. Hodges, &J. P. Hearn, 1983. The relationship between plasma progesterone and the timing of ovulation and early embryonic development in the marmoset monkey (Callithrix jacchus).J. Zool. London, 201: 273–282.
Hearn, J. P., 1983. The common marmoset (Callithrix jacchus). In:Reproduction in New World Primates,J. P. Hearn (ed.), MTP Press, Lancaster, pp. 183–215.
Heger, H. W. &D. Neubert, 1983. Timing of ovulation and implantation in the common marmoset,Callithrix jacchus, by monitoring of estrogens and 6β-hydroxypregnanolone in urineArch.Toxicol., 54: 41–52.
Hodges, J. K., 1978. Effect of gonadectomy and oestradiol treatment on plasma luteinizing hormone concentrations in the marmoset monkey,Callithrix jacchus.J. Endocrin., 76: 271–281.
Holmes, A. W., L. Wolfe, H. Rosenblate, &F. Deinhardt, 1969. Hepatitis in marmosets: induction of disease with coded specimen from a human volunteer study.Science, 165: 816–817.
Inaba, T., N. Takahashi, H. Matsuda, &T. Imori, 1984. Estrogen and progesterone receptor and progesterone metabolism in canine mammary tumours.Jap. J. Vet. Sci., 46: 797–803.
McNeilly, A. S., D. H. Abbott, S. F. Lunn, P. C. Chambers, &J. P. Hearn, 1981a. Plasma prolactin concentrations during the ovarian cycle and lactation and their relationship to return of fertility post partum in the common marmoset (Callithrix jacchus).J. Reprod. Fertil., 62: 353–360.
—,P. W. Howie, &M. J. Houston, 1981b. Relationship of feeding patterns, prolactin, and resumption of ovulation postpartum. In:Research Frontiers in Fertility Regulation,G. I. Zatuchni,M. H. Labbok, &J. J. Sciarra (eds.), Harper & Row, Mexico City, pp. 102–116.
Nigi, H. &R. Torii, 1983. Preovulatory time courses of plasma estradiol and progesterone in the Japanese monkey (Macaca fuscata).Primates, 24: 410–418.
Poswillo, D. E., W. J. Hamilton, &D. Sopher, 1972. The marmoset as an animal model for teratological research.Nature, 239: 460–462.
Provost, P. J., O. L. Ittensohn, V. M. Villarejos, &M. R. Hilleman, 1975. A specific complement-fixation test for human hepatitis a employing CR326 virus antigen. Diagnosis and epidemiology (38669).Proc. Soc. Exp. Biol. Med., 148: 962–969.
Shope, T. D., Dechairo, &G. Miller, 1973. Malignant lymphoma in cotton-top marmosets after inoculation with epstein-barr virus.Proc. Nat. Acad. Sci. U.S.A., 70: 2487–2491.
Siddall, R. A., 1978. The use of marmoset (Callithrix jacchus) in teratological and toxicological research.Prim. Med., 10: 215–224.
Torii, R., S. Utsu, &Y. Tanioka, 1981. Pituitary-adrenal function in the marmoset monkey.Folia Endocrin. Jap., 57: 1177–1185.
Werner, J., H. Wolf, J. Apodaca, &H. Z. Hauzen, 1975. Lymphoproliferative disease in a cotton-top marmoset after inoculation with infectious mononucleosis derived epstein barr virus.Int. J. Cancer, 15: 1000–1008.
Wolf, L. G., L. A. Falk, &F. Deinhardt, 1971. Oncogenicity of herpesvirus saimiri in marmoset monkeys.J. Nat. Cancer Inst., 47: 1145–1162.
Author information
Authors and Affiliations
About this article
Cite this article
Torii, R., Koizumi, H., Tanioka, Y. et al. Serum LH, progesterone and estradiol-17β levels throughout the ovarian cycle, during the early stage of pregnancy and after the parturition and the abortion in the common marmoset,Callithrix jacchus . Primates 28, 229–238 (1987). https://doi.org/10.1007/BF02382572
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02382572