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Optimization of the preparation of153Sm-EDTMP using natural samarium targets for clinical use

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Abstract

153Sm (specific activity 3.7 to 5.55 GBq/mg) was produced by irradiating natural Sm2O3 at a flux of 2.2·1013 n·cm−2·s−1. Ethylenediaminetetramethylenephosphonate (EDTMP) was synthesised according to a reported method. Complexation was carried out by varying experimental parameters such as mole ratios of metal to ligand, pH, time and temperature of reaction to obtain quantitative yields. The radiochemical purity of the complex was assessed by various analytical techniques including HPLC. In vitro ligand exchange studies were undertaken to ensure suitability of the product for therapy. Biodistribution studies were carried out in Wistar rats and adequate bone uptake, retention and rapid clearance from blood stream were observed.

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Authors and Affiliations

  1. Radiopharmaceuticals Section, Isotope Division, B.A.R.C., Trombay, 400 085, Mumbai, India

    M. A. Majali & A. R. Mathakar

  2. Radiation Medicine Centre, B.A.R.C., Parel, 400 012, Mumbai, India

    H. H. Shimpi

Authors
  1. M. A. Majali
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  2. A. R. Mathakar
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  3. H. H. Shimpi
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Majali, M.A., Mathakar, A.R. & Shimpi, H.H. Optimization of the preparation of153Sm-EDTMP using natural samarium targets for clinical use. J Radioanal Nucl Chem 240, 845–849 (1999). https://doi.org/10.1007/BF02349861

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  • DOI: https://doi.org/10.1007/BF02349861

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