Abstract
The effect on the liver of portal or bile duct branch occlusion was examined in rabbits by measuring hepatic tissue blood flow and cellular kinetics, using the bromodeoxyuridine labeling index. The portal branch bile duct branch, or both, to the main lobe and caudate lobe (80.4% of total liver weight) were ligated or embolized just above the right posterior lobe (19.6%), resulting in compensatory hypertrophy of the right posterior lobe and atrophy of the main and caudate lobes. Twenty-four days after ligation, the degree of compensatory hypertrophy in the different groups was comparable. There were significant differences in the pattern of the development of hypertrophy. Ligation of both a portal branch and the corresponding bile duct resulted in more rapid hypertrophy and atrophy than ligation of a portal branch alone. Ligation of a branch of the bile duct resulted in slow development of hypertrophy and atrophy. In the embolization group, the increase in the right posterior lobe stopped 6 days after the operation, resulting that it was about 40% thereafter. Histological findings showed that the fibrin clot had contracted and was floating in the portal branch to the main lobe. These results suggested that portal blood flow to the main lobe had resumed and was gradually increasing as the clot contracted. Portal branch ligation gave results superior to those with portal branch embolization with regard to application to preoperative procedure in extended hepatobiliary surgery.
Similar content being viewed by others
References
Rous P, Larimore LD (1920) Relationship of the portal blood to liver maintenance. J Exp Med 31:609–632
Schalm L, Bax HR, Mansens BJ (1956) Atrophy of the liver after occlusion of the bile ducts or portal vein and compensatory hypertrophy of the unoccluded portion and its clinical importance. Gastroenterology 31:131–155
Steiner PE, Martinez JB (1961) Effects on the rat liver of bile duct, portal vein, and hepatic artery ligation. Am J Pathol 39:257–289
Kozaka S, (1963) Extensive hepatectomy in two stages. Arch Jpn Chir 32:99–123
Rozga J, Jeppsson B, Bengmark S (1986) Portal branch ligation in the rat. Am J Pathol 125:300–308
Honjo I, Suzuki T, Ozawa K (1975) Ligation of a branch of the portal vein for carcinoma of the liver. Am J Surg 130: 296–302
Nishida M, Yano K, Murakami T, Suzuki T (1991) Introduction of monoclonal antibodies to bromodeoxyuridine to monitor hepatic regeneration. Gastroenterology 100:1135–1137
Kinoshita H, Sakai K, Hirohashi K, Igawa S, Yamasaki O, Kubo S (1986) Preoperative portal vein embolization for hepatocellular carcinoma. World J Surg 10:803–808
Makuuchi M, Takayasu K, Takuma T (1984) Preoperative transcatheter embolization of the portal venous branch for patients receiving extended lobectomy due to bile duct carcinoma. J Jpn Soc Clin Surg 45:1558–1564
Gratzner HG (1982) Monoclonal antibody to 5-bromo- and 5-iodo-deoxyuridine. Science 218:474–475
Shepherd AP, Riedel GL, Kiel JW, Haumschild DJ, Maxwell LC (1987) Evaluation of an infrared laser-Doppler blood flowmeter. Am J Physiol 252:G832–839
Hsu SM, Raine L, Fanger H (1981) The use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. J Histochem Cytochem 29:577–580
Benz EJ, Baggenstoss AH, Wollaeger EE (1952) Atrophy of the left lobe of the liver. Arch Pathol 53:315–330
Braasch JW, Whitcomb FF Jr, Watkins E Jr, Maguire RR, Khazei AM (1972) Segmental obstruction of the bile duct. Surg Gynecol Obstet 134:915–920
Ohlsson EG, Rutherford RB, Boitnott JK, Haalebos MMP, Zuidema GD (1970) Changes in portal circulation after biliary obstruction in dogs. Am J Surg 120:16–22
Doppman JL, Girton M, Vermess M (1982) The risk of hepatic artery embolization in the presence of obstructive jaundice. Radiology 143:37–43
Saji Y (1988) The effect of decreased portal blood flow on the biliary system. Jpn J Surg 18:558–568
Kerr JFR (1971) “Shrinkage necrosis”; a distinct mode of cellular death. J Pathol 105:13–20
Lewis WD, Cady B, Rohrer R, Jenkins RL, Benotti PN, McDermott WV (1987) Avoidance of transhepatic drainage prior to hepaticojejunostomy for obstruction of the biliary tract. Surg Gynecol Obstet 165:381–386
Author information
Authors and Affiliations
About this article
Cite this article
Nishida, M., Nakashima, K., Maeda, Y. et al. Compensatory hepatic hypertrophy after occlusion of branches of the portal vein or bile duct. J Hep Bil Pancr Surg 2, 61–67 (1995). https://doi.org/10.1007/BF02348290
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02348290