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Differential allelic expression of lactoproteins: A model to study transcriptional regulation

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Abstract

The importance of transcriptional control of gene expression has been documented in relation to several genetic defects in man. Mutations in the promoter region of genes have been shown to be responsible for defects which are characterized by over or under expression of genes. Genetic polymorphisms of the milk protein genes, and their high level of tissue specific expression during lactation, represent a suitable system for studying regulation of gene expression. Quantification of the allele specific protein products has demonstrated unequal allelic contribution in the expression of the beta lactoglobulin (β-LG) alleles A and B. The DNA sequence analysis of the β-LG promoter revealed allele specific polymorphisms related to the coding region genotypes.

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Authors and Affiliations

  1. Biotechnical Faculty, Zootechnical Department, University of Ljubljana, Groblje 3, SI-61230, Domtale, Slovenia

    Peter Dovč

  2. Department of Animal Science, University of California Davis, 95616-8521, Davis, CA, USA

    Lorraine Lum & Juan F. Medrano

Authors
  1. Peter Dovč
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  2. Lorraine Lum
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  3. Juan F. Medrano
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Dovč, P., Lum, L. & Medrano, J.F. Differential allelic expression of lactoproteins: A model to study transcriptional regulation. Pflugers Arch. 431 (Suppl 6), R203–R204 (1996). https://doi.org/10.1007/BF02346339

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  • DOI: https://doi.org/10.1007/BF02346339

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