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Effective complex formation in the interaction of 1,2-dimethyl-3-hydroxypyrid-4-one (Deferiprone or L1) with uranium(VI)

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Abstract

In an effort to develop new chelating agents for the decorporation of uranium and other actinides, the interaction of the clinically used 1,2-dimethyl-3-hydroxypyrid-4-one (Deferiprone or L1) with hexavalent uranium was investigated by using UV-VIS spectroscopy and solubility measurements. The complex stoichiometry estimation carried out by the Job plot method indicated that under normal conditions up to pH 8.0 a 1[U(VI)]∶1[L1] complex is formed. The stability constant of the UO2L1+ complex was determined by spectroscopic and solubility experiments and found to be log β11=9.1±0.3. The molar extinction coefficient at pH 7.6 for the complex at 500 nm was estimated to be 650 l·mol−1·cm−1. At ligand concentrations higher than 6·10−4 mol·l−1 the formation of a precipitate was observed. The stoichiometry UO2(L1)2 was identified following FTIR measurements of the red precipitate and UV/VIS spectroscopy after dissolution.

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Authors and Affiliations

  1. Department of Natural Sciences, University of Cyprus, P.O. Box 537, Cy-1678, Nicosia, Cyprus

    I. Pashalidis

  2. Postgraduate Research Institute of Science, Technology, Environment and Medicine, Ammochostou 3, Cy-3021, Limassol, Cyprus

    G. J. Kontoghiorghes

Authors
  1. I. Pashalidis
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  2. G. J. Kontoghiorghes
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Pashalidis, I., Kontoghiorghes, G.J. Effective complex formation in the interaction of 1,2-dimethyl-3-hydroxypyrid-4-one (Deferiprone or L1) with uranium(VI). J Radioanal Nucl Chem 242, 181–184 (1999). https://doi.org/10.1007/BF02345915

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  • DOI: https://doi.org/10.1007/BF02345915

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