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On the principles underlying the diagnosis of brain tumours — A survey article

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Summary

A survey is given of the principles underlying the diagnosis of brain tumours.

Traditionally diagnosis and localization of brain tumours have been based upon morphological criteria. Currently unsurpassed levels in imaging of anatomical details and topographical relations by the techniques of computed tomography (CT) and magnetic resonance imaging (MRI) have been achieved.

The techniques of positron emission tomography (PET) and of magnetic resonance spectroscopy (MRS), which depict also metabolic and blood flow aspects, provide a refinement of our knowledge on the metabolism, structure and pathophysiological relations of a tumour to the surrounding parenchyma.

Recent advances in the recording of function-related changes of the cerebral electro-magnetic field allow a better definition of critical functional areas.

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References

  1. Bergström M, Collins VP, Ehrin E, Ericson K, Eriksson L, Greitz T, Halldin C, Von Holst H, Langstrom B, Lilja A, Lundqvist H, Nagren K (1983) Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using [68Ga]EDTA, [11C]glucose, and [11C]methionine. J Comp Ass Tomogr 7: 1062–1066

    Google Scholar 

  2. Chandler WF, Knake JE (1984) Intraoperative use of ultrasound in neurosurgery. Clin Neurosurg 31: 550–563

    Google Scholar 

  3. Daumas-Duport C, Monsaigneon V, Blond S, Munari C, Musolino A, Chodkiewicz JP, Missir O (1987) Serial stereotactic biopsies and CT scan in gliomas: correlative study in 100 astrocytomas, oligo-astrocytomas and oligodendrogliomas. J Neurooncol 4: 317–328

    Article  CAS  PubMed  Google Scholar 

  4. Doyle WK, Budinger TF, Valk PE, Levin VA, Gutin PH (1987) Differentiation of cerebral radiation necrosis from tumor recurrence by [18F]FDG and 82Rb positron emission tomography. Neurosurgery 11: 563–570

    CAS  Google Scholar 

  5. Gloor P, Ball G, Schaul N (1977) Brain lesions that produce delta waves in the EEG. Neurology 27: 326–333

    CAS  PubMed  Google Scholar 

  6. Go KG, Hew JM, Kamman RL, Molenaar WM, Pruim J, Blaauw EH (1993) Cystic lesions of the brain. A classification based on pathogenesis, with consideration of histological and radiological features. Eur J Radiol 17: 69–84

    Article  CAS  PubMed  Google Scholar 

  7. Go KG, Van der Veen PH, Ebels EJ, Van Woudenberg F (1972) A study of electrical impedance of oedematous cerebral tissue during operations. Acta Neurochir (Wien): 113–124

  8. Go KG (1991) Cerebral pathophysiology. An integral approach with some emphasis on clinical implications. Elsevier, Amsterdam

    Google Scholar 

  9. Go KG, Wilmink JT, Molenaar WM (1988) Peritumoral brain edema associated with meningiomas. Neurosurgery 23: 175–179

    CAS  PubMed  Google Scholar 

  10. Go KG, Keuter EJW, Kamman RL, Pruim J, Metzemaekers JDM, Staal MJ, Paans AMI, Vaalburg W (1994) The contribu-11C]-tyrosine positron emission tomography to localization of cerebral gliomas for biopsy. Neurosurgery 34: 994–1002

    CAS  PubMed  Google Scholar 

  11. Go KG, Kamman RL, Wilmink JT, Mooyaart EL (1993) A CT and MRI scanning. Acta Neurochir (Wien): 41–46

  12. Grant FC (1923) Localization of brain tumors by determination of the electrical resistance of the growth. JAMA 81: 2169–2171

    Google Scholar 

  13. Heesters MAAM, Kamman RL, Mooyaart EL, Go KG (1993) Localized proton spectroscopy of inoperable brain gliomas. Response to radiation therapy. J Neurooncol 17: 27–35

    Article  CAS  PubMed  Google Scholar 

  14. Hirano A, Matsui T (1975) Vascular structures in brain tumors. Human Pathol 6: 611–621

    CAS  Google Scholar 

  15. Hubesch B, Sappey-Marinier D, Roth K, Meyerhoff DJ, Matson GB, Weiner MW (1990) P31 MR spectroscopy of normal human brain and brain tumors. Radiology 174: 401–409

    CAS  PubMed  Google Scholar 

  16. Ishiwata K, Vaalburg W, Elsinga PH, Paans AMJ, Woldring MG (1988) Comparison of L-[1–11C]methionine and L-methyl-[11C]methionine for measuring in vivo protein synthesis rates with PET. J Nucl Med 29: 1419–1427

    CAS  PubMed  Google Scholar 

  17. Kapouleas I, Alavi A, Alves WM, Gur RE, Weiss DW (1991) Registration of three-dimensional MR images of the human brain without markers. Radiology 181: 731–739

    CAS  PubMed  Google Scholar 

  18. Katada K (1990) MR imaging of brain surface structures; surface anatomy scanning (SAS). Neuroradiology 32: 439–448

    Article  CAS  PubMed  Google Scholar 

  19. Kwong KK, Belliveau JW, Chester DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Cheng HM, Brady TJ, Rosen BR (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89: 5675–5679

    CAS  PubMed  Google Scholar 

  20. Long DM (1970) Capillary ultrastructure and the blood-brain barrier in human malignant brain tumors. J Neurosurg 32: 127–144

    CAS  PubMed  Google Scholar 

  21. Lopes da Silva FH, Spekreijse H (1991) Localization of brain sources of visually evoked responses: using single and multiple dipoles. An overview of different approaches. Eventrelated Brain Research [EEG Suppl] 42: 38–46

    Google Scholar 

  22. Maier-Hauff K, Gerlach L, Cordes M (1990) HM-PAO-SPECT in the differentiation of cerebral gliomas. First experiences with blood flow measurements. In: Schneider GH, Vogler E, Kocever K (eds) Digitale Bildgebung, interventionelle Radiologie, integrierte digitale Radiologie. Blackwell Ueberreuter, pp 40–46

    Google Scholar 

  23. Moore GE (1950) Diagnosis and localization of brain tumors. Thomas, Springfield

    Google Scholar 

  24. Ogawa T, Uemura K, Shishido F, Yamaguchi T, Murakami M, Inugami A, Kanno I, Sasaki H, Kato T, Hirata K, Kowada M, Mineura K, Yasuda T (1988) Changes of cerebral blood flow, and oxygen and glucose metabolism following radiochemotherapy of gliomas. A PET study. J Comp Ass Tomogr 12: 290–297

    CAS  Google Scholar 

  25. Ogawa T, Shishido F, Kanno I, Inugami A, Fujita H, Murakami M, Shimosegawa E, Ito H, Hatazawa J, Okudera T, Uemura K, Yasui N, Mineura K (1993) Cerebral glioma: evaluation with methionine PET. Radiology 186: 45–53

    CAS  PubMed  Google Scholar 

  26. Ott D, Hennig J, Ernst T (1993) Human brain tumors: assessment with in vivo proton MR spectroscopy. Radiology 186: 745–752

    CAS  PubMed  Google Scholar 

  27. Paans AMJ, Elsinga PH, Vaalburg W (1993) Carbon-11 labeled tyrosine as a probe for modelling the protein synthesis rate. In: Mazoyer BM, Heiss WD, Comar D (eds) PET studies on amino acid metabolism and protein synthesis. Kluver, Boston, pp 161–174

    Google Scholar 

  28. Patronas NJ, Di Chiro G, Kufta C, Bairamian D, Kornblith PL, Simon R, Larson SM (1985) Prediction of survival in glioma patients by means of positron emission tomography. J Neurosurg 62: 816–822

    CAS  PubMed  Google Scholar 

  29. Penn RD (1980) Cerebral edema and neurological function CT, evoked responses and clinical examination. Adv Neurol 28: 383–394

    CAS  PubMed  Google Scholar 

  30. Warburg O (1956) On the origin of cancer cells. Science 123: 309–314

    CAS  PubMed  Google Scholar 

  31. Wieringa HJ, Peters MJ, Lopes da Silva FH (1993) The estimation of a realistic localization of dipole layers within the brain based on functional (EEG, MEG) and structural (MRI) data: a preliminary note. Brain Topogr 5: 327–330

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neurosugery, Diagnostic Radiology, University Hospital Groningen, The Netherlands

    K. G. Go

  2. Sections of Magnetic Resonance Imaging, University Hospital Groningen, The Netherlands

    R. L. Kamman & E. L. Mooyaart

  3. Sections of Neuroradiology, University Hospital Groningen, The Netherlands

    J. M. Hew

  4. Sections of Positron Emission Tomography, University Hospital Groningen, The Netherlands

    J. Pruim, W. Vaalburg & A. M. J. Paans

  5. Sections of Radiotherapy, University Hospital Groningen, The Netherlands

    M. A. A. M. Heesters

  6. Institute of Neurobiology, University of Amsterdam, The Netherlands

    F. H. Lopes da Silva

Authors
  1. K. G. Go
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  2. R. L. Kamman
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  3. J. Pruim
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  4. J. M. Hew
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  5. W. Vaalburg
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  6. A. M. J. Paans
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  7. E. L. Mooyaart
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  8. M. A. A. M. Heesters
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  9. F. H. Lopes da Silva
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Go, K.G., Kamman, R.L., Pruim, J. et al. On the principles underlying the diagnosis of brain tumours — A survey article. Acta neurochir 135, 1–11 (1995). https://doi.org/10.1007/BF02307407

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