Skip to main content
SpringerLink
Log in

Total chromatographic optimization (TOCO) II. Precision and efficiency of analysis

  • Originals
  • Published:
Chromatographia Aims and scope Submit manuscript

Summary

A chromatographic system set at an operating condition takes its own precision and efficiency which are numerically described by the information Φ called FUMI and the information flow ϑ, respectively. Optimization for a variable such as mobile phase composition draws a line in the Φ-ϑ space. This paper demonstrates that optimization of different variables displays different patterns of lines in the Φ-ϑ space. The variables examined here are mobile phase composition, column length, flow rate (velocity) and detection wavelength (or the amount of internal standard). Clear difference in the analytical roles of the variables can be known from the Φ-ϑ plots.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Y. Hayashi, R. Matsuda, A. Nakamura, Chromatographia,30, 85 (1990).

    Google Scholar 

  2. Y. Hayashi, S. Yoshioka, Y. Takeda, Anal. Sci.,5, 329 (1989).

    Google Scholar 

  3. Y. Hayashi, R. Matsuda, Anal. Chim. Acta,222, 313 (1989).

    Google Scholar 

  4. Y. Hayashi, Anal. Sci.,6, 15 (1990).

    Google Scholar 

  5. K. Jinno, K. Kawasaki, J. Chromatogr.298, 326 (1984).

    Google Scholar 

  6. H. J. G. Debets, B. L. Bajema, D. A. Doornbos, Anal. Chim. Acta,151, 131 (1983).

    Google Scholar 

  7. C. E. Goewie, J. Liquid Chromatogr.,9, 1431 (1985).

    Google Scholar 

  8. J. C. Berridge, Anal. Chim. Acta,191, 243 (1986).

    Google Scholar 

  9. P. J. Schoenmakers, J. Liquid Chromatogr.,10, 1865 (1987).

    Google Scholar 

  10. J. L. Glajch, J. J. Kirkland, J. M. Minor, J. Liquid Chromatogr.,10, 1727 (1987).

    Google Scholar 

  11. Y. Hayashi, R. Matsuda, submitted for publication.

  12. Y. Hayashi, R. Matsuda, Anal. Sci.,5, 459 (1989).

    Google Scholar 

  13. J. H. Knox, J. Chromatogr. Sci.,18, 453 (1980).

    Google Scholar 

  14. Kosoku Ekitai Kuromatogurafu Bunseki (High Performance Liquid Chromatographic Analysis), Ed. by The Japan Society of Analytical Chemistry, Kanto Region Branch, Sangyo Tosho, Tokyo, 1982.

    Google Scholar 

  15. Y. Hayashi, R. Matsuda, Anal. Sci.,6, 131 (1990).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Hygienic Sciences, 18-1, Kamiyoga 1-Chome, 158, Setagaya, Tokyo, Japan

    Y. Hayashi & R. Matsuda

Authors
  1. Y. Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Matsuda
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayashi, Y., Matsuda, R. Total chromatographic optimization (TOCO) II. Precision and efficiency of analysis. Chromatographia 30, 171–175 (1990). https://doi.org/10.1007/BF02274541

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02274541

Key Words

Search

Navigation