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Larval paralysis as an in vitro assay of levamisole and morantel tartrate resistance inOstertagia

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Abstract

The paper describes a method for detecting levamisole and morantel tartrate resistance by determining the percentage of paralysed third stage larvae in serial dilutions of anthelmintic. Levamisole resistantOstertagia spp. had a smaller proportion of larvae undergoing tonic paralysis in either levamisole or morantel tartrate than did a non-resistant strain. The dose response thus obtained for a strain of worms can be tested statistically against strains which are known to be resistant or non-resistant.

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Authors and Affiliations

  1. Division of Animal Health, Pastoral Research Laboratory, CSIRO, Private Mail Bag, P.O., 2350, Armidale, N.S.W., (Australia)

    P. J. Martin & L. F. Le Jambre

Authors
  1. P. J. Martin
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  2. L. F. Le Jambre
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Commonwealth of Australia

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Martin, P.J., Le Jambre, L.F. Larval paralysis as an in vitro assay of levamisole and morantel tartrate resistance inOstertagia . Vet Res Commun 3, 159–164 (1979). https://doi.org/10.1007/BF02268963

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  • DOI: https://doi.org/10.1007/BF02268963

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