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Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration

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Abstract

Phencyclidine (PCP; 2.5 or 5.0 mg/kg) potentiated the effects of rewarding hypothalamic brain stimulation, causing parallel leftward shifts of the functions that relate rate of responding to stimulation frequency. Thus, like a number of other drugs of abuse, PCP lowered the “dose” of stimulation required to maintain responding at a given criterion. No progressive changes in the reward-potentiating effects of PCP were evident when the rats were tested once per week for 8 weeks; there was neither tolerance nor sensitization to the initial rewarding properties of PCP. However, in subsequent locomotor tests rats appeared to be already sensitized to PCP; this raises the possibility that the electrical stimulation of the lateral hypothalamus itself maximally sensitized the animals to the stimulant effects of the drug.

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  1. Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Blvd. West, H3G 1M8, Montreal, Quebec, Canada

    William A. Carlezon Jr & Roy A. Wise

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  1. William A. Carlezon Jr
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  2. Roy A. Wise
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Carlezon, W.A., Wise, R.A. Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration. Psychopharmacology 111, 402–408 (1993). https://doi.org/10.1007/BF02253528

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  • DOI: https://doi.org/10.1007/BF02253528

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