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The auditory P300 correlates with specific cognitive deficits in Parkinson's disease

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Journal of Neural Transmission - Parkinson's Disease and Dementia Section

Summary

An abnormally prolonged latency of the P300 event-related potential has been reported in several types of dementing illnesses, including Parkinson's disease (PD). While some PD patients have dementia, a significant number of PD patients have less severe cognitive impairments. We examined the relationship between the auditory P300 and a neuropsychological battery of 11 tasks in 43 PD patients. The quantitative relationship between the individual neuropsychological measures and the P300 was examined using partial correlation and analysis of covariance techniques which controlled for age, education, and illness duration. The strongest correlations were between P300 and both shortterm memory and visual perception. Global cognitive deficits do not appear to relate to the abnormal P300 responses in PD: instead, specific aspects of cognitive decline accounted for the electrophysiological abnormalities. An abnormally long or absent P300 correlated with deficits on select cognitive tasks: those involving memory, visual perception, and abstract reasoning. The interactions between anatomical and neurochemical abnormalities in PD are discussed in light of the pattern of deficits seen in this study.

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References

  • Baddeley A (1986) Working memory. Oxford University Press, Oxford

    Google Scholar 

  • Benton A, Hamsher K (1976) Multilingual aphasia examination. University of Iowa, Iowa City

    Google Scholar 

  • Benton A, Hamsher K, Varney N, Spreen O (1983) Contributions to neuropsychological assessment: a clinical manual. Oxford University Press, New York

    Google Scholar 

  • Bodis-Wollner I, Yahr MD, Mylin LH (1984) Nonmotor functions of the basal ganglia. In: Hassler RG, Christ JR (eds) Advances in neurology. Raven Press, New York, pp 289–297

    Google Scholar 

  • Bowen F, Burns M, Brady E, Yahr MD (1972) A note on alterations of personal orientation in Parkinsonism. Neuropsychologia 14: 425–429

    Google Scholar 

  • Brown R, Marsden C (1988) Internal versus external cues and the control of attention in Parkinson's disease. Brain 111: 323–345

    Google Scholar 

  • Donchin E, Miller GA, Farwell LA (1986) The endogenous components of the event-related potential: a diagnostic tool? In: Swaab DF, Fliers E, Mirmiran M, van Gool WA, van Haaren F (eds) Progress in brain research. Elsevier Science Publishers, Amsterdam, pp 87–102

    Google Scholar 

  • Duncan-Johnson CC, Donchin E (1982) The P300 component of the event-related brain potential as an index of information processing. Biol Psychol 14: 1–52

    Google Scholar 

  • Fabiani M, Karis B, Donchin E (1986) P300 and recall in an incidental memory paradigm. Psychophysiology 23: 298–308

    Google Scholar 

  • Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61: 331–349

    Google Scholar 

  • Glover A, Ghilardi M, Bodis-Wollner I, Onofrj M (1988) Alterations in event-related potentials of MPTP-treated monkeys. Electroencephalogr Clin Neurophysiol 71: 461–468

    Google Scholar 

  • Goldman-Rakic PS, Brown RM (1981) Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neuroscience 6: 177–187

    Google Scholar 

  • Goldman-Rakic PS, Selemon LD, Schwartz ML (1984) Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey. Neuroscience 12: 719–743

    Google Scholar 

  • Goodin D, Aminoff MJ (1987) Electrophysiological differences between demented and nondemented patients with Parkinson's disease. Ann Neurol 21: 90–94

    Google Scholar 

  • Goodin D, Squires K, Henderson B, Starr A (1978a) Age-related variations in evoked potentials to auditory stimuli in normal human subjects. Electroencephalogr Clin Neurophysiol 44: 447–458

    Google Scholar 

  • Goodin D, Squires K, Starr A (1978b) Long latency event-related components of the auditory potential in dementia. Brain 101: 635–648

    Google Scholar 

  • Gotham AM, Brown RG, Marsden CD (1988) “Frontal” cognitive function in patients with Parkinson's disease “on” and “off” Levodopa. Brain 111: 299–321

    Google Scholar 

  • Graybiel AM (1986) DA-containing innervation of the striatum: subsystem and their striatal correspondents. In: Fahn S, Marsden CD, Jenner P (eds) Recent developments in Parkinson's disease. Raven Press, New York, pp 1–16

    Google Scholar 

  • Hansch E, Syndulko K, Cohen S, Goldberg Z, Potvin A, Tourrellotte W (1982) Cognition in Parkinson's disease: an event-related perspective. Ann Neurol 11: 599–607

    Google Scholar 

  • Hietanen M, Terevainen H (1986) Cognitive performance in early Parkinson's disease. Acta Neurol Scand 73: 151–159

    Google Scholar 

  • Hoehn M, Yahr M (1967) Parkinsonism: onset, progression, and mortality. Neurology 17: 427–442

    Google Scholar 

  • Homberg V, Hefter H, Granseyer G, Strauss W, Lange H, Hennerici M (1986) Event-related potentials in patients with Huntington's disease and relatives at risk in relation to detailed psychometry. Electroencephalogr Clin Neurophysiol 63: 552–569

    Google Scholar 

  • Huber S, Shuttleworth E, Paulson G (1986) Dementia in Parkinson's disease. Arch Neurol 43: 987–990

    Google Scholar 

  • Kraiuhin C, Gordon E, Stamfield P, Meares R, Howson A (1986) P300 and the effects of aging: relevance to the diagnosis of dementia. Exp Aging Res 12: 187–192

    Google Scholar 

  • Levin BE, Llabre MM, Weiner WJ (1988) Neuropsychological correlates of early Parkinson's disease: evidence for frontal lobe dysfunction. In: Kalivas PW, Nemeroff CB (eds) The mesocorticolimbic dopamine system. Ann NY Acad Sci 537: 518–520

  • Mattis S (1976) Mental Status Examination for organic mental syndrome in the elderly patient. In: Bellak L, Karasu T (eds) Geriatric psychiatry. Grune and Stratton, New York

    Google Scholar 

  • Mohr E, Fabrini G, Ruggieri S, Fedio P, Chase T (1987) Cognitive concomitants of dopamine system stimulation in Parkinsonian patients. Neurol Neurosurg Psychiatry 50: 1192–1196

    Google Scholar 

  • Mulder G, Gloerich ABM, Brookhuis KA, van Dellen HJ, Mulder LJM (1984) Stage analysis of the reaction time process using brain event-related potentials and reaction time. Psychol Rev 46: 15–32

    Google Scholar 

  • O'Donnel B, Squires N, Martz M, Chen J, Phay A (1987) Evoked potential changes and neuropsychological performance in Parkinson's disease. Biol Psychol 24: 23–37

    Google Scholar 

  • Okada Y, Kaufman L, Williamson S (1983) The hippocampal formation as a source of the slow endogenous potentials. Electroencephalogr Clin Neurophysiol 55: 417–426

    Google Scholar 

  • Pirozzolo FJ, Hansch EC, Mortimer JA, Webster, DD, Kuskowski DD (1982) Dementia in Parkinson's disease: a neuropsychological analysis. Brain Cogn 1: 71–83

    Google Scholar 

  • Polich J, Ehlers C, Otis S, Mandell A, Bloom F (1986) P300 latency reflects the degree of cognitive decline in dementing illness. Electroencephalogr Clin Neurophysiol 63: 138–144

    Google Scholar 

  • Raskin SA, Borod JC, Wasserstein J, Bodis-Wollner I, Coscia L, Yahr MD (1990) Visuospatial orientation in Parkinson's disease. Int J Neurosci 51: 9–18

    Google Scholar 

  • Raven J (1960) Guide to the standard progressive matrices. Lewis, London

    Google Scholar 

  • Sagar H, Sullivan E, Gabrieli J, Corkin S, Growdon J (1988) Temporal ordering and short-term memory deficits in Parkinson's disease. Brain 111: 525–539

    Google Scholar 

  • Sahakian B, Morris R, Evendon J, Heald A, Levy R, Philpot M, Robbins T (1988) A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 111: 695–718

    Google Scholar 

  • Shallice T (1982) Specific impairments in planning. Phil Trans Royal Soc Lond 298: 199–209

    Google Scholar 

  • Squires KC, Wickens N, Squires N, Donchin E, (1976) The effect of stimulus sequence on the waveform of the cortical event-related potential. Science 193: 1142–1146

    Google Scholar 

  • Sutton S, Braren M, Zubin J, John ER (1965) Evoked potential correlates of stimulus uncertainty. Science 150: 1187–1188

    Google Scholar 

  • Taylor AE, Saint-Cyr AJ, Lang AE (1986) Frontal lobe dysfunction in Parkinson's disease: the cortical focus of neostriatal outflow. Brain 109: 845–883

    Google Scholar 

  • Tweedy J, Langer K, McDowell F (1982) The effect of semantic relations on the memory deficits associated with Parkinson's disease. J Clin Neuropsychol 4: 235–247

    Google Scholar 

  • Wechsler D (1945) A standardized memory scale for clinical use. J Psychol 19: 87–95

    Google Scholar 

  • Wechsler D (1981) Wechsler Adult Intelligence Scale-Revised. Psychological Corporation, New York

    Google Scholar 

  • Wilson RS, Kaszniak AW, Klawans HL, Garron DC (1980) High speed memory scanning in Parkinsonism. Cortex 16: 67–72

    Google Scholar 

  • Wood CC, McCarthy G, Squires NK, Vaughan HG, Woods DL, McCallum WC (1984) Anatomical and physiological substrates of event-related potentials. In: Kanner R, Cohen J, Tueting P (eds) Brain and information: event related potentials. New York, pp 681–721

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Author notes

  1. J. C. Borod

    Present address: Department of Neurology, Mount Sinai School of Medicine, Queens College of the City University of New York, Flushing, New York, U.S.A.

Authors and Affiliations

  1. Department of Neurology, Mount Sinai School of Medicine, Queens College of the City University of New York, Flushing, New York, U.S.A.

    S. Pang, A. Hernandez, I. Bodis-Wollner, L. Mylin & M. D. Yahr

  2. Department of Psychology, Queens College of the City University of New York, 11367, Flushing, New York, U.S.A.

    J. C. Borod, A. Hernandez, S. Raskin & L. Coscia

  3. Department of Ophthalmology, Mount Sinai School of Medicine, New York, U.S.A.

    I. Bodis-Wollner

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  1. S. Pang
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  2. J. C. Borod
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  3. A. Hernandez
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  4. I. Bodis-Wollner
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  5. S. Raskin
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  6. L. Mylin
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  7. L. Coscia
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  8. M. D. Yahr
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Pang, S., Borod, J.C., Hernandez, A. et al. The auditory P300 correlates with specific cognitive deficits in Parkinson's disease. J Neural Transm Gen Sect 2, 249–264 (1990). https://doi.org/10.1007/BF02252920

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  • DOI: https://doi.org/10.1007/BF02252920

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