Abstract
A study of event-related P300 potential and cerebral EEG maps was performed in 20 patients affected by multi-infarct dementia (MID): 10 subjects were treated with placebo and 10 with cytidine. The trial was divided into three intervals. The patients, after a period of washout, were evaluated throughout the course of the trial by electrophysiological examination performed at baseline, after 90 min from the first IV injection, again after 30 days of IM therapy, and finally after 60 days of continued IM therapy. In the group treated with cytidine, the findings relevant to the study of the P300 showed a significant decrease in latency values compared to baseline (P<0.05 ANOVA) and an improvement, though not significant, in the amplitude values. Calculation of the mean relative power of EEG values showed a significant decrease in delta activity and an increase in alpha activity. In the subjects treated with placebo, no statistically significant variation was found in either P300 or EEG map recordings. On the basis of these investigations it has been demonstrated that the variations in the registrations can be correlated to the improved neuronal activity following treatment with cytidine.
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Agnoli A, Manna V, Bocoli V, Matucci N (1981) Chronic cerebrovascular disorders: modification of the EEG spectral analysis determined by dehydroergocristine methasulphonate. Curr Ther Res 9:321–326
Agnoli A, Martucci N, Manna V, Conti L, Fioravanti M (1983) Effect of cholinergic and anticholinergic drugs of short-term memory in Alzheimer's dementia: a neuropsychological and computerized electroencephalographic study. Clin Neuropharmacol 6:311–323
Benzi A, Arrigoni E, Marzatico F, Villa R (1979) Influence of some biological pyrimidines on the succinate cycle during and after cerebral ischemia. Biol Pharmacol 28:2545–2550
Cosmi F, Caresia L, Panebianco G (1986) Nimodipina e diidroergotossina. Clin Ter 116:213–220
Donchin E (1977) Surprise?... Surprise!... Psychophysiology 25:145–152
Duffy F, Burchfiel J, Lombroso C (1979) Brain electrical activity mapping (BEAM): a method for extending the clinical utility of EEG and evoked potential data. Ann Neurol 5:309–321
Duffy F, Albert M, McAnulty G, Garvey A (1984) Age relation differences in brain electrical activity of healthy subjects. Ann Neurol 16:439–448
Duncan-Johnson C (1981) P300 latency: a new metric of information processing. Psychophysiology 18:207–215
Firenze C, Mazzotta G, Mattelli L, Bruni A, Montesi S, Gallai V (1988) Studio della P300 mediante mappe cerebrali in soggetti con vascolopatia cerebrale cronica dopo terapia con l'associazione citidina, uridina, N-acetil-glutamina. In: Atti del IX corso di aggiornamento della Società Italiana di Neurologia. Assisi, pp 210–213
Firenze C, Mazzotta G, Montesi S, Gallai V (1989) Studio della P300 e delle mappe cerebrali in soggetti con demenza multiifartuale (MID) trattati con l'associazione citidina, uridina,l-glutamina. Basi Raz Ter 19:683–688
Fischer C (1978) Dementia in cerebrovascular disease. In: Trans VI Congress Cerebrovascular Disease. Grune and Stratton, New York, pp 89–102
Floridi A, Vecchini A, Palmerini CA, Binaglia L, Porcellati G (1981) Cytidine diphosphate choline (CDP-choline) uptake by cultured brain cells. Ital J Biochem 30:317–324
Folstein M, Folstein S, McHugh P (1977) “Mini mental state”: a practical method for grading the cognitive state of patients for the clinic. J Psychiatr Res 12:189–198
Geiger A, Yamasaki S (1956) Cytidine and uridine requirement of the brain. J Neurochem 1:93–96
Gershon S, Herman S (1982) The differential diagnosis of dementia. J Am Geriatr Soc 30:2–58
Goodin D, Squires K, Starr A (1978) Long latency event-related components of, the auditory evoked potential in dementia. Brain 101:635–648
Hachinski V, Lassen NA, Marshall J (1974) Multiinfarct dementia: a cause of mental deterioration in the elderly. Lancet II:207–213
Harrison M, Marsden C (1977) Progressive intellectual deterioration. Arch Neurol 34:199–205
Hughes C, Berg I, Danziger W, Cohen I, Marin R (1982) A new clinical scale for the staging of dementia. Br J Psychiatry 140:556–572
Hylliard S, Kutas M (1983) Electrophysiology of cognitive processing. Annu Rev Psychology 34:33–61
Katz R, Horowitz G (1982) The septuagenarian EEG: studies in a selected normal geriatric population. J Am Geriatr Soc 3:273–276
Loeb C, Gandolfo C (1983) Diagnostic evaluation of degenerative and vascular dementia. Stroke 14:399–405
Mahendra B (1983) Dementia: a survey of the syndrome of dementia. MTP Press Limited, pp 167–183
Manna V, Martucci N (1990) Effects of short term administration of cytidine, uridine andl-glutamine, alone or in combination, on the cerebral electrical activity of patients with chronic cerebrovascular disease. Acta Neurol (in press)
Martucci N, Caratazzolo P, Ciabatti P, Proietti R, Manna V (1986) Le cerebopatie vascolari croniche: Valutazione clinica neuropsicologica dell'effetto del trattamento con citidina, uridina,l-glutamina in associazione. Giornale Ital Neuropsicofarm 8:267–274
Matejcek M, Knor K, Piquet P, Weil C (1979) Correlazioni fra variazioni elettroencefalografiche e cliniche in pazienti geriatrici trattati per tre mesi con hydergina. J Am Geriatr Soc 27:198–205
Nagata K, Tagawa K, Shisido F, Uemura K (1986) Topographic EEG correlates of cerebral blood flow and oxygen consumption in patients with neuropsychological disorders. In: Duffy F (ed) Topographic mapping of brain electrical activity. Butterworths, Boston, pp 357–370
O'Connor K (1977) Contingent negative variation: CNV differences between elderly normal and demented subjects. EEG Clin Neurophysiol 51:666–670
Pedley T, Miller J (1983) Clinical neurophysiology of aging and dementia. In: Mayeux R (ed) The dementias. Raven Press, New York, pp 78–93
Robins RK (1975) Nucleotides and nucleosides: past, present and future. Ann New York Acad Sci 255:597–601
Roth M (1981) The diagnosis of dementia in late and middle life. In: Mortimer J, Schuman L (eds) The epidemiology of dementia. Oxford University Press, New York, pp 45–51
Roubicek J (1977) The EEG in the middle-aged and the elderly. J Am Geriatr Soc 25:145–152
Spinnler H (1985) Il decadimento demenziale. Inquadramento neurologico e neuropsicologico. Il Pensiero Scientifico (ed), Roma
Trovarelli G, Palmerini CA, Floridi A, Piccinin GL, Porcellati G (1984) The influence of cytidine on the endogenous pool of CDP-choline, CDP-ethanolamine and CMP of the rat brain. J Neurochem Res 9:73–79
Villardita C, Smirni P, Bozzanca L, Nicoletti F, Drago F (1983) Effects of pyrimidine nucleosides and N-acetyl-glutamine on learning and memory in men of various ages. Acta Ther 9:407–416
Wisniewski H, Terry RD (1976) Neuropathology of the aging brain. In: Terry RD, Gershon S (eds) Aging. Raven Press, New York
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Gallai, V., Mazzotta, G., Firenze, C. et al. Study of the P300 and cerebral maps in subjects with multi-infarct dementia treated with cytidine. Psychopharmacology 103, 1–5 (1991). https://doi.org/10.1007/BF02244066
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DOI: https://doi.org/10.1007/BF02244066