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Inhibitory action of alcohol on human exocrine pancreatic secretion

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Abstract

The effects of intragastric and intravenous ethanol administration on exocrine secretion of human pancreas were studied in 15 subjects. By either route, ethanol administration substantially reduced volume, concentration and output of bicarbonates, lipase and chymotrypsin. This action is interpreted as direct inhibition of the pancreas by ethanol. However, calcium concentration in duodenal juice increased with intragastric ethanol administration and decreased with intravenous ethanol administration.

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Authors and Affiliations

  1. From the Unité de Recherches de Pathologie Digestive, INSERM, 46 Chemin de la Gaye, 13, Marseille (9e), France

    Carlos Mott,  Henri Sarles, Osvalso Tiscornia & Lucio Gullo

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  1. Carlos Mott
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  2. Henri Sarles
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  3. Osvalso Tiscornia
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  4. Lucio Gullo
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Mott, C., Sarles, H., Tiscornia, O. et al. Inhibitory action of alcohol on human exocrine pancreatic secretion. Digest Dis Sci 17, 902–910 (1972). https://doi.org/10.1007/BF02239528

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  • DOI: https://doi.org/10.1007/BF02239528

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