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Short-term regulation of hepatic triacylglycerol metabolism by insulin and glucagon

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Abstract

This paper presents a review of our current knowledge of short-term regulation of triacylglycerol metabolism by insulin and glucagon in isolated rat hepatocytes. Insulin is devoted to rapidly improve the lipogenic climate of the hepatocyte. The hormone stimulates glycolysis, the conversion of pyruvate into acetyl-CoA, the synthesis of fatty acids and their esterification. The opposite pathways, hydrolysis of triacylglycerols and fatty acid oxidation, are depressed by insulin. Glucagon does all but deteriorate the lipogenic climate within the liver cell as the hormone inhibits triacylglycerol synthesis and stimulates the breakdown of triacylglycerols.

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Author notes

  1. A. C. Beynen

    Present address: Department of Human Nutrition, Agricultural University, De Dreijen 12, 6703 BC, Wageningen, The Netherlands

Authors and Affiliations

  1. Laboratory of Veterinary Biochemistry, State University of Utrecht, Biltstraat 172, 3572 BP, Utrecht, The Netherlands

    A. C. Beynen & M. J. H. Geelen

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  1. A. C. Beynen
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  2. M. J. H. Geelen
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Beynen, A.C., Geelen, M.J.H. Short-term regulation of hepatic triacylglycerol metabolism by insulin and glucagon. Vet Res Commun 5, 223–236 (1981). https://doi.org/10.1007/BF02214989

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